Quassidine B

CAS# 1207862-37-0

Quassidine B

Catalog No. BCN7022----Order now to get a substantial discount!

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Quality Control of Quassidine B

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Chemical structure

Quassidine B

3D structure

Chemical Properties of Quassidine B

Cas No. 1207862-37-0 SDF Download SDF
PubChem ID 46184321 Appearance Powder
Formula C27H24N4O3 M.Wt 452.51
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-(4,8-dimethoxy-9H-pyrido[3,4-b]indol-1-yl)-1-(9H-pyrido[3,4-b]indol-1-yl)propan-1-ol
SMILES COC1=CC=CC2=C1NC3=C2C(=CN=C3CCC(C4=NC=CC5=C4NC6=CC=CC=C56)O)OC
Standard InChIKey WVRVQNNTQSYWRT-UHFFFAOYSA-N
Standard InChI InChI=1S/C27H24N4O3/c1-33-21-9-5-7-17-23-22(34-2)14-29-19(26(23)31-24(17)21)10-11-20(32)27-25-16(12-13-28-27)15-6-3-4-8-18(15)30-25/h3-9,12-14,20,30-32H,10-11H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Quassidine B

The stems of Picrasma quassioides.

Biological Activity of Quassidine B

DescriptionQuassidine B is a natural product from Picrasma quassioides.

Protocol of Quassidine B

Structure Identification
Journal of Natural Products, 2010, 73(2):167-171.

Quassidines A-D, bis-beta-carboline alkaloids from the stems of Picrasma quassioides.[Pubmed: 20095629]


METHODS AND RESULTS:
Four new bis-beta-carboline alkaloids, quassidine A,Quassidine B, quassidine C, quassidine D (1-4), together with a known alkaloid, picrasidine C (5), were isolated from the stems of Picrasma quassioides. Quassidine A (1) is the first reported bis-beta-carboline alkaloid possessing a novel cyclobutane moiety. The structures of the new compounds were determined on the basis of their 1D and 2D NMR and X-ray diffraction data.
CONCLUSIONS:
A possible biogenetic pathway for these alkaloids was proposed, and all compounds were evaluated for anti-inflammatory activity. Only quassidine A (1) showed weak activity.

Quassidine B Dilution Calculator

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Quassidine B Molarity Calculator

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Preparing Stock Solutions of Quassidine B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2099 mL 11.0495 mL 22.099 mL 44.1979 mL 55.2474 mL
5 mM 0.442 mL 2.2099 mL 4.4198 mL 8.8396 mL 11.0495 mL
10 mM 0.221 mL 1.1049 mL 2.2099 mL 4.4198 mL 5.5247 mL
50 mM 0.0442 mL 0.221 mL 0.442 mL 0.884 mL 1.1049 mL
100 mM 0.0221 mL 0.1105 mL 0.221 mL 0.442 mL 0.5525 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Quassidine B

Quassidines A-D, bis-beta-carboline alkaloids from the stems of Picrasma quassioides.[Pubmed:20095629]

J Nat Prod. 2010 Feb 26;73(2):167-71.

Four new bis-beta-carboline alkaloids, quassidines A-D (1-4), together with a known alkaloid, picrasidine C (5), were isolated from the stems of Picrasma quassioides. Quassidine A (1) is the first reported bis-beta-carboline alkaloid possessing a novel cyclobutane moiety. The structures of the new compounds were determined on the basis of their 1D and 2D NMR and X-ray diffraction data. A possible biogenetic pathway for these alkaloids was proposed, and all compounds were evaluated for anti-inflammatory activity. Only quassidine A (1) showed weak activity.

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