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Obscuraminol F

CAS# 350485-01-7

Obscuraminol F

Catalog No. BCN1768----Order now to get a substantial discount!

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Quality Control of Obscuraminol F

Number of papers citing our products

Chemical structure

Obscuraminol F

3D structure

Chemical Properties of Obscuraminol F

Cas No. 350485-01-7 SDF Download SDF
PubChem ID 101101129 Appearance Oil
Formula C16H33NO M.Wt 255.44
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3R)-2-aminohexadec-15-en-3-ol
SMILES CC(C(CCCCCCCCCCCC=C)O)N
Standard InChIKey BBZHHOGHQKXCRQ-JKSUJKDBSA-N
Standard InChI InChI=1S/C16H33NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-16(18)15(2)17/h3,15-16,18H,1,4-14,17H2,2H3/t15-,16+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Obscuraminol F

The Pseudodistoma obscurum

Protocol of Obscuraminol F

Structure Identification
Tetrahedron, 2001, 57(21):4579-4588.

Obscuraminols, new unsaturated amino alcohols from the tunicate Pseudodistoma obscurum: structure and absolute configuration.[Reference: WebLink]


METHODS AND RESULTS:
The study of the ascidian Pseudodistoma obscurum from Tarifa Island (Cádiz, Spain) has led to the characterization of six new unsaturated 2-amino-3-ol compounds, the obscuraminols A-F. Five of them, the obscuraminol B, Obscuraminol C, Obscuraminol D, Obscuraminol E, Obscuraminol F, were isolated as their corresponding diacetyl derivatives.
CONCLUSIONS:
Their structures were established by spectroscopic analysis, their relative configurations by NOEDS study of oxazolidinone derivatives, and their absolute configurations by application of Mosher's method to N-acetyl derivatives.

Obscuraminol F Dilution Calculator

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Obscuraminol F Molarity Calculator

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Preparing Stock Solutions of Obscuraminol F

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9148 mL 19.5741 mL 39.1481 mL 78.2963 mL 97.8703 mL
5 mM 0.783 mL 3.9148 mL 7.8296 mL 15.6593 mL 19.5741 mL
10 mM 0.3915 mL 1.9574 mL 3.9148 mL 7.8296 mL 9.787 mL
50 mM 0.0783 mL 0.3915 mL 0.783 mL 1.5659 mL 1.9574 mL
100 mM 0.0391 mL 0.1957 mL 0.3915 mL 0.783 mL 0.9787 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Obscuraminol F

Testosterone-induced modulation of peroxisomal morphology and peroxisome-related gene expression in brown trout (Salmo trutta f. fario) primary hepatocytes.[Pubmed:29032351]

Aquat Toxicol. 2017 Dec;193:30-39.

Disruption of androgenic signaling has been linked to possible cross-modulation with other hormone-mediated pathways. Therefore, our objective was to explore effects caused by testosterone - T (1, 10 and 50muM) in peroxisomal signaling of brown trout hepatocytes. To study the underlying paths involved, several co-exposure conditions were tested, with flutamide - F (anti-androgen) and ICI 182,780 - ICI (anti-estrogen). Molecular and morphological approaches were both evaluated. Peroxisome proliferator-activated receptor alpha (PPARalpha), catalase and urate oxidase were the selected targets for gene expression analysis. The vitellogenin A gene was also included as a biomarker of estrogenicity. Peroxisome relative volumes were estimated by immunofluorescence, and transmission electron microscopy was used for qualitative morphological control. The single exposures of T caused a significant down-regulation of urate oxidase (10 and 50muM) and a general up-regulation of vitellogenin. A significant reduction of peroxisome relative volumes and smaller peroxisome profiles were observed at 50muM. Co-administration of T and ICI reversed the morphological modifications and vitellogenin levels. The simultaneous exposure of T and F caused a significant and concentration-dependent diminishing in vitellogenin expression. Together, the findings suggest that in the tested model, T acted via both androgen and estrogen receptors to shape the peroxisomal related targets.

Iron chloride catalysed PCDD/F-formation: Experiments and PCDD/F-signatures.[Pubmed:29031055]

Chemosphere. 2018 Jan;191:72-80.

Iron chloride is often cited as catalyst of PCDD/F-formation, together with copper chloride. Conversely, iron chloride catalysis has been less studied during de novo tests. This paper presents such de novo test data, derived from model fly ash incorporating iron (III) chloride and established over a vast range of temperature and oxygen concentration in the gas phase. Both PCDD/F-output and its signature are extensively characterised, including homologue and congener profiles. For the first time, a complete isomer-specific analysis is systematically established, for all samples. Special attention is paid to the chlorophenols route PCDD/F, to the 2,3,7,8-substituted congeners, and to their relationship and antagonism.

Viscum articulatum Burm. f.: a review on its phytochemistry, pharmacology and traditional uses.[Pubmed:29034952]

J Pharm Pharmacol. 2018 Feb;70(2):159-177.

OBJECTIVES: The aim of this study was to review and highlight traditional and ethnobotanical uses, phytochemical constituents, IP status, biological activity and pharmacological activity of Viscum articulatum. METHODS: Thorough literature searches were performed on Viscum articulatum, and data were analysed for reported traditional uses, pharmacological activity, phytochemicals present and patents filed. Scientific and patent databases such as PubMed, Science Direct, Google Scholar, Google patents, USPTO and Espacenet were searched using different keywords. KEY FINDINGS: Viscum articulatum has been traditionally used in different parts of the world for treatment of various ailments. Almost all the parts such as leaves, root, stem and bark are having medicinal values and are reported for their uses in Ayurvedic and Chinese system of medicine for the management of various diseases. Modern scientific studies demonstrate efficacy of this plant against hypertension, ulcer, epilepsy, inflammation, wound, nephrotoxicity, HIV, cancer, etc. Major bioactive phytochemicals include oleanolic acid, betulinic acid, eriodictyol, naringenin, beta-amyrin acetate, visartisides, etc. CONCLUSIONS: Side effects of allopathic medicines have created a global opportunity, acceptance and demand for phytomedicines. Viscum articulatum could be an excellent source of effective and safe phytomedicine for various ailments if focused translational efforts are undertaken by integrating the existing outcomes of researches.

Cytotoxic Dibohemamines D-F from a Streptomyces Species.[Pubmed:29035560]

J Nat Prod. 2017 Oct 27;80(10):2825-2829.

Three dimeric analogues of bohemamines, dibohemamines D-F (1-3), together with dibohemamine A (4), were isolated from Streptomyces sp. CPCC 200497. Their structures were solved using a combination of mass spectrometry, 1D and 2D NMR spectroscopy, and CD. Dibohemamines D and E were new dimeric analogues of bohemamines, and dibohemamine F was a known compound obtained previously by semisynthesis. Dibohemamine F displayed potent cytotoxicity against cancer cell lines A549 and HepG2 with IC50 values of 1.1 and 0.3 muM, respectively. Dibohemamines D and E showed moderate cytotoxicity against cancer cell lines A549 and HepG2.

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