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Neocurdione

CAS# 108944-67-8

Neocurdione

Catalog No. BCC9242----Order now to get a substantial discount!

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Chemical structure

Neocurdione

3D structure

Chemical Properties of Neocurdione

Cas No. 108944-67-8 SDF Download SDF
PubChem ID 24836956 Appearance Powder
Formula C15H24O2 M.Wt 236.4
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3R,6Z,10S)-6,10-dimethyl-3-propan-2-ylcyclodec-6-ene-1,4-dione
SMILES CC1CCC=C(CC(=O)C(CC1=O)C(C)C)C
Standard InChIKey KDPFMRXIVDLQKX-BLJGWETHSA-N
Standard InChI InChI=1S/C15H24O2/c1-10(2)13-9-14(16)12(4)7-5-6-11(3)8-15(13)17/h6,10,12-13H,5,7-9H2,1-4H3/b11-6-/t12-,13+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Neocurdione

The rhizomes of Curcuma zedoaria

Biological Activity of Neocurdione

Description1. Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis. 2. Neocurdione shows a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50 mg/kg p.o.
TargetsNO | TNF-α | Caspase

Neocurdione Dilution Calculator

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Neocurdione Molarity Calculator

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Preparing Stock Solutions of Neocurdione

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.2301 mL 21.1506 mL 42.3012 mL 84.6024 mL 105.753 mL
5 mM 0.846 mL 4.2301 mL 8.4602 mL 16.9205 mL 21.1506 mL
10 mM 0.423 mL 2.1151 mL 4.2301 mL 8.4602 mL 10.5753 mL
50 mM 0.0846 mL 0.423 mL 0.846 mL 1.692 mL 2.1151 mL
100 mM 0.0423 mL 0.2115 mL 0.423 mL 0.846 mL 1.0575 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Neocurdione

9-Oxo-neoprocurcumenol from Curcuma aromatica (Zingiberaceae) as an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis.[Pubmed:12784640]

Biosci Biotechnol Biochem. 2003 Apr;67(4):911-3.

Neocurdione, isoprocurcumenol, and a new sesquiterpene, 9-oxo-neoprocurcumenol, were isolated from fresh rhizomes of Curcuma aromatica and Curcuma zedoaria (Zingiberaceae) as attachment inhibitors against the blue mussel, Mytilus edulis galloprovincialis. The structures of these compounds were elucidated on the basis of spectroscopic evidence.

[Studies on chemical constituents of Curcuma aromatica salisb].[Pubmed:12212100]

Zhongguo Zhong Yao Za Zhi. 2000 Mar;25(3):163-5.

OBJECTIVE: To study the effective ingredients of Curcuma aromatica. METHOD: Solvent extraction was used. The constituents were isolated with resin D-101 silica gel column and thin-layer chromatography, and the structures were elucidated by physico-chemical properties and spectral analysis. RESULT: Curdione, Neocurdione, curcumol, tetramethylpyrazine and (R)-(+)-1,2-hexadecanediol were isolated from C. aromatica. CONCLUSION: Neocurdione and (R)-(+)-1,2-hexadecanediol were isolated from C. aromatica for the first time, and was isolated from Curcuma and reported for the first time.

Description

Neocurdione is a hepatoprotective sesquiterpene isolated from Curcuma zedoaria rhizome. Neocurdione exerts potent effect on D-galactosamine- (D-Gain) and lipopolysaccharide- (LPS) induced acute liver injury in mice.

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