Murrayone

CAS# 19668-69-0

Murrayone

Catalog No. BCN5331----Order now to get a substantial discount!

Product Name & Size Price Stock
Murrayone:5mg Please Inquire In Stock
Murrayone:10mg Please Inquire In Stock
Murrayone:20mg Please Inquire In Stock
Murrayone:50mg Please Inquire In Stock

Quality Control of Murrayone

Number of papers citing our products

Chemical structure

Murrayone

3D structure

Chemical Properties of Murrayone

Cas No. 19668-69-0 SDF Download SDF
PubChem ID 5319964 Appearance White cryst.
Formula C15H14O4 M.Wt 258.27
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 7-methoxy-8-(3-methyl-2-oxobut-3-enyl)chromen-2-one
SMILES CC(=C)C(=O)CC1=C(C=CC2=C1OC(=O)C=C2)OC
Standard InChIKey IISMOXLSZASLDD-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H14O4/c1-9(2)12(16)8-11-13(18-3)6-4-10-5-7-14(17)19-15(10)11/h4-7H,1,8H2,2-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Murrayone

The leaves of Murraya koenigii

Biological Activity of Murrayone

DescriptionMurrayone can significantly inhibit the abnormal increase of platelet aggregation induced by ADP.
In vitro

Coumarins from Leonurus japonicus and their anti-platelet aggregative activity[Pubmed: 25850267]

Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4356-9.

Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18.
METHODS AND RESULTS:
Structures of the isolates were determined by spectroscopic analysis as 10 coumarins: bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), Murrayone(8) , auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time.
CONCLUSIONS:
In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.

Murrayone Dilution Calculator

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Murrayone Molarity Calculator

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Preparing Stock Solutions of Murrayone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8719 mL 19.3596 mL 38.7192 mL 77.4383 mL 96.7979 mL
5 mM 0.7744 mL 3.8719 mL 7.7438 mL 15.4877 mL 19.3596 mL
10 mM 0.3872 mL 1.936 mL 3.8719 mL 7.7438 mL 9.6798 mL
50 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.5488 mL 1.936 mL
100 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.7744 mL 0.968 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Murrayone

[Coumarins from Leonurus japonicus and their anti-platelet aggregative activity].[Pubmed:25850267]

Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4356-9.

Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18. Structures of the isolates were determined by spectroscopic analysis as 10 coumarins: bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), Murrayone(8) , auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time. In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.

Description

Murrayone, a coumarin-containing compound extracted from M. paniculata, is the most bioactive substance in this species and is a cancer metastasis chemopreventive agent based on its unique pharmacological properties.

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