Mcl1-IN-1Myeloid cell factor 1 inhibitor CAS# 713492-66-1 |
Related Products
- C646
Catalog No.:BCC4546
CAS No.:328968-36-1
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 713492-66-1 | SDF | Download SDF |
| PubChem ID | 2966040 | Appearance | Powder |
| Formula | C23H18ClN3O4 | M.Wt | 435.86 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 50 mg/mL (114.72 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-[2-[(5-chloro-8-hydroxyquinolin-7-yl)-(pyridin-2-ylamino)methyl]phenoxy]acetic acid | ||
| SMILES | C1=CC=C(C(=C1)C(C2=CC(=C3C=CC=NC3=C2O)Cl)NC4=CC=CC=N4)OCC(=O)O | ||
| Standard InChIKey | VMEDTSNKTYMQLG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H18ClN3O4/c24-17-12-16(23(30)22-14(17)7-5-11-26-22)21(27-19-9-3-4-10-25-19)15-6-1-2-8-18(15)31-13-20(28)29/h1-12,21,30H,13H2,(H,25,27)(H,28,29) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Mcl1-IN-1 Dilution Calculator
Mcl1-IN-1 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2943 mL | 11.4716 mL | 22.9431 mL | 45.8863 mL | 57.3579 mL |
| 5 mM | 0.4589 mL | 2.2943 mL | 4.5886 mL | 9.1773 mL | 11.4716 mL |
| 10 mM | 0.2294 mL | 1.1472 mL | 2.2943 mL | 4.5886 mL | 5.7358 mL |
| 50 mM | 0.0459 mL | 0.2294 mL | 0.4589 mL | 0.9177 mL | 1.1472 mL |
| 100 mM | 0.0229 mL | 0.1147 mL | 0.2294 mL | 0.4589 mL | 0.5736 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Mcl1-IN-1 is a small molecule, potent and selective inhibitor of myeloid cell factor 1 (Mcl-1) with an IC50 value of 2.4 μM [1].
Mcl1-IN-1 has been reported to potently inhibit Mcl-1 which acted as an important therapeutic target for the treatment of non-solid tumor and solid tumor malignancies with an IC50 value of 2.4 μM. The inhibition ability of Mcl1-IN-1 to Mcl-1 was 40-fold more than Bcl-xL of which IC50 is 100 μM. Mcl1-IN-1 has the favorable physicochemical properties, for example, lack of any apparent toxicophores [1].
References:
[1] Richard DJ1, Lena R, Bannister T, Blake N, Pierceall WE, Carlson NE, Keller CE, Koenig M, He Y, Minond D, Mishra J, Cameron M, Spicer T, Hodder P, Cardone MH.Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1; 21(21):6642-9.
Featured Products
- Moclobemide (Ro 111163)
Catalog No.:BCC2322
CAS No.:71320-77-9
- 6(1H)-Azulenone, 2,3-dihydro-1,4-dimethyl
Catalog No.:BCN1371
CAS No.:71305-89-0
- (S)-3-Hydroxyphenylglycine
Catalog No.:BCC6605
CAS No.:71301-82-1
- Cronaburmine
Catalog No.:BCN2072
CAS No.:71295-32-4
- Crotananine
Catalog No.:BCN2078
CAS No.:71295-28-8
- 2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene
Catalog No.:BCC8503
CAS No.:7128-64-5
- Salaspermic acid
Catalog No.:BCN7139
CAS No.:71247-78-4
- Boc-Ala(2-pyridyl)-OH
Catalog No.:BCC3320
CAS No.:71239-85-5
- Obolactone
Catalog No.:BCN7190
CAS No.:712272-88-3
- Schizandriside
Catalog No.:BCN6999
CAS No.:71222-06-5
- Erythroxytriol P
Catalog No.:BCN4274
CAS No.:7121-99-5
- ML 141
Catalog No.:BCC8092
CAS No.:71203-35-5
New Products
- APETx2
Catalog No.:BCC6294
CAS No.:713544-47-9
- Jatropholone B
Catalog No.:BCC8192
CAS No.:71386-38-4
- 3-Methyl-GABA
Catalog No.:BCC6629
CAS No.:71424-95-8
- Plinabulin (NPI-2358)
Catalog No.:BCC5094
CAS No.:714272-27-2
- Methylecgonine
Catalog No.:BCN1908
CAS No.:7143-09-1
- Sylvestroside I
Catalog No.:BCN4163
CAS No.:71431-22-6
- TTNPB (Arotinoid Acid)
Catalog No.:BCC4874
CAS No.:71441-28-6
- Z-D-Asp(OtBu)-OH.H2O
Catalog No.:BCC2785
CAS No.:71449-08-6
- H-D-Val-OMe.HCl
Catalog No.:BCC3147
CAS No.:7146-15-8
- Vinorelbine
Catalog No.:BCN2543
CAS No.:71486-22-1
- AC480 (BMS-599626)
Catalog No.:BCC1252
CAS No.:714971-09-2
- Safrolglycol
Catalog No.:BCN4596
CAS No.:7154-01-0
Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 µM).
Mcl1-IN-1,713492-66-1,Natural Products,Bcl-2 Family, buy Mcl1-IN-1 , Mcl1-IN-1 supplier , purchase Mcl1-IN-1 , Mcl1-IN-1 cost , Mcl1-IN-1 manufacturer , order Mcl1-IN-1 , high purity Mcl1-IN-1
