HMBA LinkerCAS# 3006-96-0 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 3006-96-0 | SDF | Download SDF |
| PubChem ID | 76360 | Appearance | Powder |
| Formula | C8H8O3 | M.Wt | 152.2 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-(hydroxymethyl)benzoic acid | ||
| SMILES | C1=CC(=CC=C1CO)C(=O)O | ||
| Standard InChIKey | WWYFPDXEIFBNKE-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C8H8O3/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4,9H,5H2,(H,10,11) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
HMBA Linker Dilution Calculator
HMBA Linker Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.5703 mL | 32.8515 mL | 65.703 mL | 131.406 mL | 164.2576 mL |
| 5 mM | 1.3141 mL | 6.5703 mL | 13.1406 mL | 26.2812 mL | 32.8515 mL |
| 10 mM | 0.657 mL | 3.2852 mL | 6.5703 mL | 13.1406 mL | 16.4258 mL |
| 50 mM | 0.1314 mL | 0.657 mL | 1.3141 mL | 2.6281 mL | 3.2852 mL |
| 100 mM | 0.0657 mL | 0.3285 mL | 0.657 mL | 1.3141 mL | 1.6426 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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HMBA Linker
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C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles.[Pubmed:26924021]
Org Biomol Chem. 2016 Mar 28;14(12):3238-45.
A large variety of C-terminally modified peptides was obtained by nucleophilic cleavage of the ester bond in solid phase linked peptide esters of 4-hydroxymethyl benzamide (HMBA). The developed methods provided peptides, C-terminally functionalized as esters, amides and thioesters, with high purity directly from the resin in a single reaction step. A comprehensive screening of the reaction conditions and scope for nucleophilic cleavage of peptides from the HMBA Linker was performed.
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