Ganoderic acid ZCAS# 294674-09-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 294674-09-2 | SDF | Download SDF |
| PubChem ID | 10601916 | Appearance | Powder |
| Formula | C30H42O7 | M.Wt | 514.66 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E,4S,6R)-4-hydroxy-6-[(3S,5R,10S,13R,14R,17R)-3-hydroxy-4,4,10,13,14-pentamethyl-7,11,15-trioxo-1,2,3,5,6,12,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-2-methylhept-2-enoic acid | ||
| SMILES | CC(CC(C=C(C)C(=O)O)O)C1CC(=O)C2(C1(CC(=O)C3=C2C(=O)CC4C3(CCC(C4(C)C)O)C)C)C | ||
| Standard InChIKey | PRJBNEAPLDQWLQ-AVCLMWMBSA-N | ||
| Standard InChI | InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h11,15,17-18,21-22,31,34H,8-10,12-14H2,1-7H3,(H,36,37)/b16-11+/t15-,17+,18-,21+,22+,28+,29-,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines. 2. The binding affinities of ganoderic acid DM and Z (ΔGbind, −16.83 and−10.99 kcal mol−1) are comparable to that of current commercial drug oseltamivir (−23.62 kcal mol−1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors. |
| Targets | Antifection |
Ganoderic acid Z Dilution Calculator
Ganoderic acid Z Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.943 mL | 9.7152 mL | 19.4303 mL | 38.8606 mL | 48.5758 mL |
| 5 mM | 0.3886 mL | 1.943 mL | 3.8861 mL | 7.7721 mL | 9.7152 mL |
| 10 mM | 0.1943 mL | 0.9715 mL | 1.943 mL | 3.8861 mL | 4.8576 mL |
| 50 mM | 0.0389 mL | 0.1943 mL | 0.3886 mL | 0.7772 mL | 0.9715 mL |
| 100 mM | 0.0194 mL | 0.0972 mL | 0.1943 mL | 0.3886 mL | 0.4858 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- L 006235
Catalog No.:BCC2361
CAS No.:294623-49-7
- Ticarcillin sodium
Catalog No.:BCC4737
CAS No.:29457-07-6
- Sophorabioside
Catalog No.:BCN7838
CAS No.:2945-88-2
- Pseudolycorine
Catalog No.:BCN5371
CAS No.:29429-03-6
- 4',7-Di-O-methylnaringenin
Catalog No.:BCN5197
CAS No.:29424-96-2
- 7-Nitroindazole
Catalog No.:BCC6713
CAS No.:2942-42-9
- Cyclen
Catalog No.:BCN8441
CAS No.:294-90-6
- Secoisolariciresinol
Catalog No.:BCN5196
CAS No.:29388-59-8
- Anhydrosecoisolariciresinol
Catalog No.:BCN7521
CAS No.:29388-33-8
- Ro 90-7501
Catalog No.:BCC7351
CAS No.:293762-45-5
- Thevetiaflavone
Catalog No.:BCN4024
CAS No.:29376-68-9
- T0901317
Catalog No.:BCC1178
CAS No.:293754-55-9
- Narciclasine
Catalog No.:BCN4732
CAS No.:29477-83-6
- Cypellocarpin C
Catalog No.:BCN7556
CAS No.:294856-66-9
- Valerosidate
Catalog No.:BCN6750
CAS No.:29505-31-5
- MNI-caged-L-glutamate
Catalog No.:BCC7086
CAS No.:295325-62-1
- Eupatoletin
Catalog No.:BCN3605
CAS No.:29536-44-5
- Olivil
Catalog No.:BCN5198
CAS No.:2955-23-9
- Negletein
Catalog No.:BCN8085
CAS No.:29550-13-8
- (E)-N-Caffeoylputrescine
Catalog No.:BCC8391
CAS No.:29554-26-5
- Sakuranetin
Catalog No.:BCN5199
CAS No.:2957-21-3
- 2-Amino-2',5-dichlorobenzophenone
Catalog No.:BCC8520
CAS No.:2958-36-3
- Gynuramide II
Catalog No.:BCN5200
CAS No.:295803-03-1
- Friedelin 3,4-lactone
Catalog No.:BCN6449
CAS No.:29621-75-8
Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells.[Pubmed:10923835]
Chem Pharm Bull (Tokyo). 2000 Jul;48(7):1026-33.
Six new highly oxygenated lanostane-type triterpenes, called ganoderic acid gamma (1), ganoderic acid delta (2), ganoderic acid epsilon (3), Ganoderic acid Zeta (4), ganoderic acid eta (5) and ganoderic acid theta (6), were isolated from the spores of Ganoderma lucidum, together with known ganolucidic acid D (7) and ganoderic acid C2 (8). Their structures of the new triterpenes were determined as (23S)-7beta,15alpha,23-trihydroxy-3,11-dioxolanosta-8, 24(E)-diene-26-oic acid (1), (23S)-7alpha,15alpha23-trihydroxy-3,11-dioxolanosta-8, 24(E)-diene-26-oic acid (2), (23S)-3beta3,7beta, 23-trihydroxy-11,15-dioxolanosta-8,24(E)-diene-26-oic acid (3), (23S)-3beta,23-dihydroxy-7,11,15-trioxolanosta-8, 24(E)-diene-26-oic acid (4), (23S)-3beta,7beta,12beta,23-tetrahydroxy-11,15-dioxolanos ta-8,24(E)-diene-26-oic acid (5) and (23S)-3beta,12beta23-trihydroxy-7,11,15-trioxolanosta-8,24(E )-diene-26-oic acid (6), respectively, by chemical and spectroscopic means, which included the determination of a chiral center in the side chain by a modification of Mosher's method. The cytotoxicity of the compounds isolated from the Ganoderma spores was carried out in vitro against Meth-A and LLC tumor cell lines.
Novel binding patterns between ganoderic acids and neuraminidase: Insights from docking, molecular dynamics and MM/PBSA studies.[Pubmed:26905206]
J Mol Graph Model. 2016 Apr;65:27-34.
Recently, ganoderic acids (GAs) give rise to the attractive candidates of novel neuraminidase (NA) inhibitors. However, there is still no evident conclusion about their binding patterns. To this end, docking, molecular dynamics and MM/PBSA methods were combined to study the binding profiles of GAs with the N1 protein and familiar H274Y and N294S mutations (A/Vietnam/1203/04 stain). It was found that the binding affinities of ganoderic acid DM and Z (DeltaGbind, -16.83 and -10.99 kcal mol(-1)) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol(-1)). Electrostatic interaction is the main driving force, and should be one important factor to evaluate the binding quality and rational design of NA inhibitors. The 150-loop residues Asp151 and Arg152 played an important role in the binding processes. Further analysis revealed that ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir. It had steric hindrance on the 150 cavity of N1 protein, and exerted activities across the H274Y and N294S mutations. This work also pointed out how to effectively design dual-site NA inhibitors and reinforce their affinities. These findings should prove valuable for the in-depth understanding of interactions between NA and GAs, and warrant the experimental aspects to design novel anti-influenza drugs.
