Ganoderenic acid ACAS# 100665-40-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 100665-40-5 | SDF | Download SDF |
| PubChem ID | 6442088 | Appearance | Powder |
| Formula | C30H42O7 | M.Wt | 514.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E)-6-[(7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxohept-5-enoic acid | ||
| SMILES | CC(CC(=O)C=C(C)C1CC(C2(C1(CC(=O)C3=C2C(CC4C3(CCC(=O)C4(C)C)C)O)C)C)O)C(=O)O | ||
| Standard InChIKey | OVUOUFPIPZJGME-HRKVNZLKSA-N | ||
| Standard InChI | InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h10,16,18-19,21,23,32,35H,8-9,11-14H2,1-7H3,(H,36,37)/b15-10+/t16?,18-,19+,21?,23+,28+,29-,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The fruiting bodys of Ganoderma lucidum
| Description | 1. Ganoderenic acid A show inhibitory activity on human aldose reductase in vitro. 2. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury. 3. Ganoderenic acid A has cytotoxic activity, their inhibitory activities against human HeLa cervical cancer cell lines. |
Ganoderenic acid A Dilution Calculator
Ganoderenic acid A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9429 mL | 9.7144 mL | 19.4288 mL | 38.8576 mL | 48.572 mL |
| 5 mM | 0.3886 mL | 1.9429 mL | 3.8858 mL | 7.7715 mL | 9.7144 mL |
| 10 mM | 0.1943 mL | 0.9714 mL | 1.9429 mL | 3.8858 mL | 4.8572 mL |
| 50 mM | 0.0389 mL | 0.1943 mL | 0.3886 mL | 0.7772 mL | 0.9714 mL |
| 100 mM | 0.0194 mL | 0.0971 mL | 0.1943 mL | 0.3886 mL | 0.4857 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum.[Pubmed:10077435]
Biol Pharm Bull. 1999 Feb;22(2):162-4.
To prove the relationship between the fluctuation in serum beta-glucuronidase level and hepatotoxicity, an inhibitor of beta-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent beta-glucuronidase-inhibitory activity, protected against CCl4-induced liver injury. From this ether fraction, Ganoderenic acid A, was isolated as the potent inhibitor of beta-glucuronidase. It had a potent hepatoprotective effect against CCl4-induced liver injury. These results suggest that the beta-glucuronidase seems to be closely related to liver injury, which could be prevented by beta-glucuronidase inhibitors.
Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum.[Pubmed:20379959]
Planta Med. 2010 Oct;76(15):1691-3.
CHCl(3) extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and Ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and Ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.
Ganoderenic acid A is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury.
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