Frangulin BCAS# 14101-04-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 14101-04-3 | SDF | Download SDF |
| PubChem ID | 442744 | Appearance | Yellow powder |
| Formula | C20H18O9 | M.Wt | 402.4 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-1,8-dihydroxy-6-methylanthracene-9,10-dione | ||
| SMILES | CC1=CC(=C2C(=C1)C(=O)C3=CC(=CC(=C3C2=O)O)OC4C(C(CO4)(CO)O)O)O | ||
| Standard InChIKey | AEQMIFRODRFTJF-SLFFLAALSA-N | ||
| Standard InChI | InChI=1S/C20H18O9/c1-8-2-10-14(12(22)3-8)17(25)15-11(16(10)24)4-9(5-13(15)23)29-19-18(26)20(27,6-21)7-28-19/h2-5,18-19,21-23,26-27H,6-7H2,1H3/t18-,19-,20+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Frangulin B Dilution Calculator
Frangulin B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4851 mL | 12.4254 mL | 24.8509 mL | 49.7018 mL | 62.1272 mL |
| 5 mM | 0.497 mL | 2.4851 mL | 4.9702 mL | 9.9404 mL | 12.4254 mL |
| 10 mM | 0.2485 mL | 1.2425 mL | 2.4851 mL | 4.9702 mL | 6.2127 mL |
| 50 mM | 0.0497 mL | 0.2485 mL | 0.497 mL | 0.994 mL | 1.2425 mL |
| 100 mM | 0.0249 mL | 0.1243 mL | 0.2485 mL | 0.497 mL | 0.6213 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Frangulin B, an antagonist of collagen-induced platelet aggregation and adhesion, isolated from Rhamnus formosana.[Pubmed:8165593]
Thromb Haemost. 1993 Dec 20;70(6):1014-8.
Emodin and its glycoside Frangulin B were isolated from the plant Rhamnus formosana. Emodin inhibited the aggregation of rabbit platelets induced by arachidonic acid and collagen, without affecting that by ADP or PAF, while emodin acetate had no any antiplatelet effect. Frangulin B inhibited selectively and concentration-dependently collagen-induced aggregation and ATP release in rabbit platelets, without affecting those induced by arachidonic acid, ADP, PAF and thrombin. Frangulin B also inhibited the platelet aggregation induced by trimucytin which was reported to be a collagen receptor agonist isolated from Trimeresurus muscrosquamatus snake venom. The aggregability of platelets inhibited by Frangulin B could be recovered after washing the platelets. Frangulin B also selectively suppressed the thromboxane B2 formation caused by collagen, but not those by arachidonic acid and thrombin. Similarly, the formation of inositol phosphate caused by collagen was also suppressed by Frangulin B, while that of PAF or thrombin was not affected. In the presence of PGE1, Frangulin B also decreased Mg(2+)-dependent platelet adhesion to collagen. It is concluded that Frangulin B may be an antagonist of collagen receptor in platelet membrane.
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