FPH1 (BRD-6125)Hepatocyte functional proliferation enhancer CAS# 708219-39-0 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 708219-39-0 | SDF | Download SDF |
| PubChem ID | 2210370 | Appearance | Powder |
| Formula | C16H15ClF2N2O3S | M.Wt | 388.82 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | 2-(5-chloro-2-methyl-N-methylsulfonylanilino)-N-(2,6-difluorophenyl)acetamide | ||
| SMILES | CC1=C(C=C(C=C1)Cl)N(CC(=O)NC2=C(C=CC=C2F)F)S(=O)(=O)C | ||
| Standard InChIKey | WAOBCCBUTHNTFO-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H15ClF2N2O3S/c1-10-6-7-11(17)8-14(10)21(25(2,23)24)9-15(22)20-16-12(18)4-3-5-13(16)19/h3-8H,9H2,1-2H3,(H,20,22) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | FPH1 is a small molecule that promotes the functional proliferation of primary hepatocytes. | |||||
| Targets | primary human hepatocytes | |||||
FPH1 (BRD-6125) Dilution Calculator
FPH1 (BRD-6125) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5719 mL | 12.8594 mL | 25.7188 mL | 51.4377 mL | 64.2971 mL |
| 5 mM | 0.5144 mL | 2.5719 mL | 5.1438 mL | 10.2875 mL | 12.8594 mL |
| 10 mM | 0.2572 mL | 1.2859 mL | 2.5719 mL | 5.1438 mL | 6.4297 mL |
| 50 mM | 0.0514 mL | 0.2572 mL | 0.5144 mL | 1.0288 mL | 1.2859 mL |
| 100 mM | 0.0257 mL | 0.1286 mL | 0.2572 mL | 0.5144 mL | 0.643 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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FPH1 is a small molecule that promotes the functional proliferation of primary hepatocytes [1].
FPH1 belongs to the functional proliferation hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. This ability of FPH1 is not dependent on the donors of the hepatocytes. It has been found that FPH1 was active against the primary human hepatocytes from six cell sources of genetically diverse individuals. Besides that, FPH1 can affect the hepatocyte functions with promoting albumin secretion during the differentiation of iPS cells into iHeps. Moreover, treatment of FPH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion [1].
References:
[1] Shan J, Schwartz R E, Ross N T, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology, 2013.
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FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes.
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