Cyclo(Ile-Val)

CAS# 104068-43-1

Cyclo(Ile-Val)

Catalog No. BCN2410----Order now to get a substantial discount!

Product Name & Size Price Stock
Cyclo(Ile-Val):10mg $329.00 In stock
Cyclo(Ile-Val):20mg $559.00 In stock
Cyclo(Ile-Val):50mg $1316.00 In stock
Cyclo(Ile-Val):100mg $2303.00 In stock

Quality Control of Cyclo(Ile-Val)

Number of papers citing our products

Chemical structure

Cyclo(Ile-Val)

3D structure

Chemical Properties of Cyclo(Ile-Val)

Cas No. 104068-43-1 SDF Download SDF
PubChem ID 10443165 Appearance Powder
Formula C11H20N2O2 M.Wt 212.29
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-butan-2-yl-6-propan-2-ylpiperazine-2,5-dione
SMILES CCC(C)C1C(=O)NC(C(=O)N1)C(C)C
Standard InChIKey XIQXUFYJMBDYSU-UHFFFAOYSA-N
Standard InChI InChI=1S/C11H20N2O2/c1-5-7(4)9-11(15)12-8(6(2)3)10(14)13-9/h6-9H,5H2,1-4H3,(H,12,15)(H,13,14)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cyclo(Ile-Val)

The roots of Panax notoginseng (Burk.)F.H.Chen

Biological Activity of Cyclo(Ile-Val)

DescriptionCyclo(Ile-Val) shows moderate antifungal and weak antitumor activities in vitro.
TargetsAntifection
In vitro

Antifungal cyclopeptides from Halobacillus litoralis YS3106 of marine origin[Reference: WebLink]

Tetrahedron Lett.,2002,33(51):6545-8.


METHODS AND RESULTS:
Three new cyclopeptides, including halolitoralin A (a cyclic hexapeptide), halolitoralin B and C (two cyclic tetrapeptides), together with three known cyclic dipeptides, cyclo(Pro-Val), cyclo(Pro-Leu) and Cyclo(Ile-Val) were isolated from the ferment broth of a marine sediment-derived Halobacillus litoralis YS3106.
CONCLUSIONS:
The cyclopeptides show surprisingly simple architectures with highly repeated residue units, which showed moderate antifungal and weak antitumor activities in vitro.

Protocol of Cyclo(Ile-Val)

Structure Identification
《Chinese Journal of Marine Drugs》 2014-03

Research on cyclo-dipeptides from the Coral-derived bacteria Brevibacterium sp.of South China Sea(Ⅱ)[Reference: WebLink]

To study cyclo-dipeptides from the Coral-derived bacteria Brevibacterium sp.of South China Sea.
METHODS AND RESULTS:
Compounds were isolated by all kinds of column chromatography,such as silica gel,Sephadex LH-20,ODS,and purified by HPLC.Their structures were identified by spectroscopic analysis(NMR,MS,GC-MS,and so on),chemicophysical methods,and compared with references. Twelve compounds were isolated from the fermentation broth of Coral-derived bacteria L-4of South China Sea,and their structures were determined as cyclo-(Trp-Thr)(1),cyclo-(4-OH-ProTyr)(2),cyclo-(Leu-Tyr)(3),cyclo-(Phe-Ala)(4),cyclo-(Ile-Gly)(5),cyclo-(Leu-Gly)(6),cyclo-(Leu-Pro)(7),cyclo-(Leu-Ala)(8),cyclo-(Ile-Ala)(9),cyclo-(Leu-Thr)(10),Cyclo(Ile-Val)(11),cyclo-(Ile-Ile)(12).
CONCLUSIONS:
All compounds were cyclo-dipeptides and first obtained from the marine Coral-derived bacteriumBrevibacteriumsp.

Cyclo(Ile-Val) Dilution Calculator

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Cyclo(Ile-Val) Molarity Calculator

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Preparing Stock Solutions of Cyclo(Ile-Val)

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.7105 mL 23.5527 mL 47.1054 mL 94.2107 mL 117.7634 mL
5 mM 0.9421 mL 4.7105 mL 9.4211 mL 18.8421 mL 23.5527 mL
10 mM 0.4711 mL 2.3553 mL 4.7105 mL 9.4211 mL 11.7763 mL
50 mM 0.0942 mL 0.4711 mL 0.9421 mL 1.8842 mL 2.3553 mL
100 mM 0.0471 mL 0.2355 mL 0.4711 mL 0.9421 mL 1.1776 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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