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Clopidogrel Related Compound A

CAS# 144457-28-3

Clopidogrel Related Compound A

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Product Name & Size Price Stock
Clopidogrel Related Compound A:5mg Please Inquire In Stock
Clopidogrel Related Compound A:10mg Please Inquire In Stock
Clopidogrel Related Compound A:20mg Please Inquire In Stock
Clopidogrel Related Compound A:50mg Please Inquire In Stock

Quality Control of Clopidogrel Related Compound A

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Chemical structure

Clopidogrel Related Compound A

3D structure

Chemical Properties of Clopidogrel Related Compound A

Cas No. 144457-28-3 SDF Download SDF
PubChem ID 9861403 Appearance Powder
Formula C15H14ClNO2S M.Wt 307.8
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid
SMILES C1CN(CC2=C1SC=C2)C(C3=CC=CC=C3Cl)C(=O)O
Standard InChIKey DCASRSISIKYPDD-AWEZNQCLSA-N
Standard InChI InChI=1S/C15H14ClNO2S/c16-12-4-2-1-3-11(12)14(15(18)19)17-7-5-13-10(9-17)6-8-20-13/h1-4,6,8,14H,5,7,9H2,(H,18,19)/t14-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Clopidogrel Related Compound A

The Clopidogrel

Biological Activity of Clopidogrel Related Compound A

DescriptionClopidogrel Related Compound A is a impurity from Clopidogrel.

Protocol of Clopidogrel Related Compound A

Structure Identification
Der Pharma Chemica;2010,2(4):244.

Non chiral High Performance Liquid Chromatography method for monitoring unknown impurities generated during stability of Clopidogrel tablets[Reference: WebLink]

The purpose of this study was to develop a High performance liquid chromatography (HPLC) method for separating the unknown impurities generated during the accelerated stability storage of Clopidogrel Bisulphate Tablets. Also, we used the newly developed method to identify the factors that contribute to the formation of these unknown impurities in the tablet formulation.
METHODS AND RESULTS:
Study was carried out by incubation of mixture of excipients and Clopidogrel API in 5:1 ratio at 80°C for 3days. The new HPLC method was developed by using Kromasil 100 C18 column and using gradient method with mobile phase of 0.1% Triflouroacetic acid in water in pump A and 0.1% Trifluoroacetic acid in Acetonitrile in pump B was suitable for separating the unknown impurities from the Clopidogrel Related Compound A.The method discussed in United States Pharmacopoeia (USP) is not suitable to separate these impurities. From the excipients compatibility data we hypothesized that these unknown impurities were generated due to the excipient Polyethylene Glycol that is present in the tablet both as a tablet lubricant as well as a part of the film coating system. Further these unknown impurities were characterized as Dihydro pyridinone Derivative, Decarbmethoxylated Clopidogrel.

Clopidogrel Related Compound A Dilution Calculator

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Clopidogrel Related Compound A Molarity Calculator

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Preparing Stock Solutions of Clopidogrel Related Compound A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2489 mL 16.2443 mL 32.4886 mL 64.9773 mL 81.2216 mL
5 mM 0.6498 mL 3.2489 mL 6.4977 mL 12.9955 mL 16.2443 mL
10 mM 0.3249 mL 1.6244 mL 3.2489 mL 6.4977 mL 8.1222 mL
50 mM 0.065 mL 0.3249 mL 0.6498 mL 1.2995 mL 1.6244 mL
100 mM 0.0325 mL 0.1624 mL 0.3249 mL 0.6498 mL 0.8122 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Clopidogrel Related Compound A

Non chiral High Performance Liquid Chromatography method for monitoring unknown impurities generated during stability of Clopidogrel tablets

Der Pharma Chemica;2010, Vol. 2 Issue 4, p244

The purpose of this study was to develop a High performance liquid chromatography (HPLC) method for separating the unknown impurities generated during the accelerated stability storage of Clopidogrel Bisulphate Tablets. Also, we used the newly developed method to identify the factors that contribute to the formation of these unknown impurities in the tablet formulation. Study was carried out by incubation of mixture of excipients and Clopidogrel API in 5:1 ratio at 80°C for 3days. The new HPLC method was developed by using Kromasil 100 C18 column and using gradient method with mobile phase of 0.1% Triflouroacetic acid in water in pump A and 0.1% Trifluoroacetic acid in Acetonitrile in pump B was suitable for separating the unknown impurities from the Clopidogrel Related Compound A.

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