Beta-Aflatrem

CAS# 144446-23-1

Beta-Aflatrem

Catalog No. BCN6699----Order now to get a substantial discount!

Product Name & Size Price Stock
Beta-Aflatrem:5mg Please Inquire In Stock
Beta-Aflatrem:10mg Please Inquire In Stock
Beta-Aflatrem:20mg Please Inquire In Stock
Beta-Aflatrem:50mg Please Inquire In Stock

Quality Control of Beta-Aflatrem

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Chemical structure

Beta-Aflatrem

3D structure

Chemical Properties of Beta-Aflatrem

Cas No. 144446-23-1 SDF Download SDF
PubChem ID 90659015 Appearance Powder
Formula C32H39NO4 M.Wt 501.66
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,4R,5S,16S,19S,23R)-19-hydroxy-4,5,24,24-tetramethyl-11-(2-methylbut-3-en-2-yl)-25,26-dioxa-7-azaheptacyclo[21.2.1.01,20.04,19.05,16.06,14.08,13]hexacosa-6(14),8(13),9,11,20-pentaen-22-one
SMILES CC1(C2C(=O)C=C3C4(CCC5CC6=C(C5(C4(CCC3(O2)O1)C)C)NC7=C6C=C(C=C7)C(C)(C)C=C)O)C
Standard InChIKey ONMXSHAELZXSPO-SDPXOEJRSA-N
Standard InChI InChI=1S/C32H39NO4/c1-8-27(2,3)18-9-10-22-20(15-18)21-16-19-11-12-31(35)24-17-23(34)26-28(4,5)37-32(24,36-26)14-13-29(31,6)30(19,7)25(21)33-22/h8-10,15,17,19,26,33,35H,1,11-14,16H2,2-7H3/t19-,26-,29+,30+,31+,32-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Beta-Aflatrem

The Aspergillus flavus

Biological Activity of Beta-Aflatrem

DescriptionStandard reference
In vitro

Indole diterpenoids and isocoumarin from the fungus, Aspergillus flavus, isolated from the prawn, Penaeus vannamei.[Pubmed: 24983640 ]

Mar Drugs. 2014 Jun 30;12(7):3970-81.


METHODS AND RESULTS:
Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (Beta-Aflatrem,4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation broth of the marine-derived fungus, Aspergillus flavus OUCMDZ-2205. The structures of Compounds 1-12 were elucidated by spectroscopic analyses, quantum ECD calculations and the chemical method.
CONCLUSIONS:
New Compound 1 exhibited antibacterial activity against Staphylococcus aureus with a MIC value of 20.5 μM. Both new Compounds 1 and 2 could arrest the A549 cell cycle in the S phase at a concentration of 10 μM. Compound 1 showed PKC-beta inhibition with an IC50 value of 15.6 μM. In addition, the absolute configurations of the known compounds, 4-6 and leporin A (6a), were also determined for the first time.

Beta-Aflatrem Dilution Calculator

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Beta-Aflatrem Molarity Calculator

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Preparing Stock Solutions of Beta-Aflatrem

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9934 mL 9.9669 mL 19.9338 mL 39.8676 mL 49.8345 mL
5 mM 0.3987 mL 1.9934 mL 3.9868 mL 7.9735 mL 9.9669 mL
10 mM 0.1993 mL 0.9967 mL 1.9934 mL 3.9868 mL 4.9835 mL
50 mM 0.0399 mL 0.1993 mL 0.3987 mL 0.7974 mL 0.9967 mL
100 mM 0.0199 mL 0.0997 mL 0.1993 mL 0.3987 mL 0.4983 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Beta-Aflatrem

Indole diterpenoids and isocoumarin from the fungus, Aspergillus flavus, isolated from the prawn, Penaeus vannamei.[Pubmed:24983640]

Mar Drugs. 2014 Jun 30;12(7):3970-81.

Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known Beta-Aflatrem (4), paspalinine (5), leporin B (6), alpha-cyclopiazonic acid (7), iso-alpha-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation broth of the marine-derived fungus, Aspergillus flavus OUCMDZ-2205. The structures of Compounds 1-12 were elucidated by spectroscopic analyses, quantum ECD calculations and the chemical method. New Compound 1 exhibited antibacterial activity against Staphylococcus aureus with a MIC value of 20.5 muM. Both new Compounds 1 and 2 could arrest the A549 cell cycle in the S phase at a concentration of 10 muM. Compound 1 showed PKC-beta inhibition with an IC50 value of 15.6 muM. In addition, the absolute configurations of the known compounds, 4-6 and leporin A (6a), were also determined for the first time.

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