Calcifediol-D6Deuterated form of Calcifediol CAS# 78782-98-6 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 78782-98-6 | SDF | Download SDF |
| PubChem ID | 66577010 | Appearance | Powder |
| Formula | C27H44O2 | M.Wt | 400.6 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO | ||
| Chemical Name | (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol | ||
| SMILES | CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C | ||
| Standard InChIKey | JWUBBDSIWDLEOM-QFVHMXLQSA-N | ||
| Standard InChI | InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1/i3D3,4D3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Calcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase
IC50 value:
Target:
This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. References: | |||||
Calcifediol-D6 Dilution Calculator
Calcifediol-D6 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4963 mL | 12.4813 mL | 24.9626 mL | 49.9251 mL | 62.4064 mL |
| 5 mM | 0.4993 mL | 2.4963 mL | 4.9925 mL | 9.985 mL | 12.4813 mL |
| 10 mM | 0.2496 mL | 1.2481 mL | 2.4963 mL | 4.9925 mL | 6.2406 mL |
| 50 mM | 0.0499 mL | 0.2496 mL | 0.4993 mL | 0.9985 mL | 1.2481 mL |
| 100 mM | 0.025 mL | 0.1248 mL | 0.2496 mL | 0.4993 mL | 0.6241 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Calcifediol-D6 is the deuterated form of Calcifediol (25-hydroxy Vitamin D3). Calcifediol is a prehormone that is a major circulating metabolite of vitamin D3.
In vitro: Calcifediol acted as a competitive inhibitor with an apparent Ki value of 3.9 μM. It also inhibited PTH secretion and mRNA with ED50 value of 2 nM.
In vivo: Oral calcifediol (biweekly or monthly regimens) was effective and safe in improving blood 25(OH)D levels and in decreasing PTH in kidney transplant recipients [1]. Calcifediol administration improved lipid profile in osteopenic atorvastatin-treated postmenopausal women [2].
Clinical trial: Correct calcium intake plus calcifediol (15 μg/day if bodyweight <20 kg; 25 μg>30 kg; oral administration) can improve bone mineral density in some young patients with cystic fibrosis [3]. Modified-release (MR) formulation of calcifediol (30, 60 or 90 μg; oral administration) was safe and highly effective in treating secondary hyperparathyroidism associated with vitamin D insufficiency in chronic kidney disease [4]. Calcifediol (20 μg) improved gait speed in young postmenopausal women compared with vitamin D3 (20 μg) [5].
References:
1. Barros X, Rodriguez NY, Fuster D, Rodas L, Esforzado N, Mazza A, et al. Comparison of two different vitamin D supplementation regimens with oral calcifediol in kidney transplant patients. J Nephrol. 2015.
2. Catalano A, Morabito N, Basile G, Cucinotta D, Lasco A. Calcifediol improves lipid profile in osteopenicatorvastatin-treated postmenopausal women. Eur J Clin Invest. 2015;45(2):144-9.
3. Bianchi ML, Colombo C, Assael BM, Dubini A, Lombardo M, Quattrucci S, et al. Treatment of low bone density in young people with cystic fibrosis: a multicentre, prospective, open-label observational study of calcium and calcifediol followed by a randomised placebo-controlled trial of alendronate. Lancet Respir Med. 2013;1(5):377-85.
4. Sprague SM, Silva AL, Al-Saghir F, Damle R, Tabash SP, Petkovich M, et al. Modified-release calcifediol effectively controls secondary hyperparathyroidism associated with vitamin D insufficiency in chronic kidney disease. Am J Nephrol. 2014;40(6):535-45.
5. Meyer O, Dawson-Hughes B, Sidelnikov E, Egli A, Grob D, Staehelin HB, et al. Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial. Osteoporos Int. 2015;26(1):373-81.
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