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Bisdethiobis(methylthio)gliotoxin

CAS# 74149-38-5

Bisdethiobis(methylthio)gliotoxin

Catalog No. BCN7351----Order now to get a substantial discount!

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Bisdethiobis(methylthio)gliotoxin:5mg Please Inquire In Stock
Bisdethiobis(methylthio)gliotoxin:10mg Please Inquire In Stock
Bisdethiobis(methylthio)gliotoxin:20mg Please Inquire In Stock
Bisdethiobis(methylthio)gliotoxin:50mg Please Inquire In Stock

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Chemical structure

Bisdethiobis(methylthio)gliotoxin

3D structure

Chemical Properties of Bisdethiobis(methylthio)gliotoxin

Cas No. 74149-38-5 SDF Download SDF
PubChem ID 194564 Appearance Powder
Formula C15H20N2O4S2 M.Wt 356.45
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3R,5aS,6S,10aR)-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylsulfanyl)-6,10-dihydro-5aH-pyrazino[1,2-a]indole-1,4-dione
SMILES CN1C(=O)C2(CC3=CC=CC(C3N2C(=O)C1(CO)SC)O)SC
Standard InChIKey OVBAGMZLGLXSBN-UOVKNHIHSA-N
Standard InChI InChI=1S/C15H20N2O4S2/c1-16-12(20)14(22-2)7-9-5-4-6-10(19)11(9)17(14)13(21)15(16,8-18)23-3/h4-6,10-11,18-19H,7-8H2,1-3H3/t10-,11-,14+,15+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Bisdethiobis(methylthio)gliotoxin

The fermentation products of Penicillium terlikowskii.

Biological Activity of Bisdethiobis(methylthio)gliotoxin

Description1. Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TargetsPAFR

Bisdethiobis(methylthio)gliotoxin Dilution Calculator

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Bisdethiobis(methylthio)gliotoxin Molarity Calculator

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Preparing Stock Solutions of Bisdethiobis(methylthio)gliotoxin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8054 mL 14.0272 mL 28.0544 mL 56.1089 mL 70.1361 mL
5 mM 0.5611 mL 2.8054 mL 5.6109 mL 11.2218 mL 14.0272 mL
10 mM 0.2805 mL 1.4027 mL 2.8054 mL 5.6109 mL 7.0136 mL
50 mM 0.0561 mL 0.2805 mL 0.5611 mL 1.1222 mL 1.4027 mL
100 mM 0.0281 mL 0.1403 mL 0.2805 mL 0.5611 mL 0.7014 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Bisdethiobis(methylthio)gliotoxin

A new diketopiperazine alkaloid from Aspergillus oryzae.[Pubmed:24116376]

Nat Prod Res. 2014;28(2):86-94.

Investigation of bioactive secondary metabolites from terrestrial Aspergillus oryzae sp. MMAO1 using M2 medium afforded a new diketopiperazine alkaloid, 7,9-dihydroxy-3-(1H-indol-3-ylmethyl)-8-methoxy-2,3,11,11a-tetrahydro-6H-pyrazino [1,2-b]isoquinoline-1,4-dione (1a), containing the unusual amino acid L-6,8-dihydroxy-7-methoxyphenylalanine. This was co-isolated with ditryptophenaline (2), cyclo-(Tryp,Tyr) (4), cyclo-(Pro,Val), alpha-cyclopiazonic acid (3), kojic acid and uridine. Re-cultivation of the fungal strain on Dox medium led to the production of bisdethio(bismethylthio)gliotoxin (5), pseurotin A (6) along with linoleic acid, alpha-cyclopiazonic acid (3) and kojic acid. The chemical structure of the new diketopiperazine alkaloid including the relative configuration was determined by 1D and 2D NMR spectroscopy and HR-ESI-MS spectrometry, and by comparison with the related literature. The new alkaloid (1a) showed no antimicrobial activity or cytotoxicity against brine shrimps.

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