Artemicapin CCAS# 334007-19-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 334007-19-1 | SDF | Download SDF |
| PubChem ID | 11629819 | Appearance | White powder |
| Formula | C10H6O5 | M.Wt | 206.2 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO | ||
| Chemical Name | 4-hydroxy-[1,3]dioxolo[4,5-h]chromen-8-one | ||
| SMILES | C1OC2=C(C=C3C=CC(=O)OC3=C2O1)O | ||
| Standard InChIKey | BKFIQORTLXDLHQ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H6O5/c11-6-3-5-1-2-7(12)15-8(5)10-9(6)13-4-14-10/h1-3,11H,4H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Reference standards. | |||||
Artemicapin C Dilution Calculator
Artemicapin C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.8497 mL | 24.2483 mL | 48.4966 mL | 96.9932 mL | 121.2415 mL |
| 5 mM | 0.9699 mL | 4.8497 mL | 9.6993 mL | 19.3986 mL | 24.2483 mL |
| 10 mM | 0.485 mL | 2.4248 mL | 4.8497 mL | 9.6993 mL | 12.1242 mL |
| 50 mM | 0.097 mL | 0.485 mL | 0.9699 mL | 1.9399 mL | 2.4248 mL |
| 100 mM | 0.0485 mL | 0.2425 mL | 0.485 mL | 0.9699 mL | 1.2124 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Potent alpha-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris.[Pubmed:23435948]
Arch Pharm Res. 2013 May;36(5):542-52.
As a part of our ongoing effort to identify anti-diabetic constituents from natural sources, we examined the inhibitory activity of the methanol extracts of 12 species of the genus Artemisia, against alpha-glucosidase and protein tyrosine phosphatase 1B (PTP1B). The methanol extracts of different species exhibited promising alpha-glucosidase and PTP1B inhibitory activities. Since the methanol extract of Artemisia capillaris exhibited the highest alpha-glucosidase inhibitory activity together with significant PTP1B inhibitory activity, it was selected for further investigation. Repeated column chromatography based on bioactivity guided fractionation yielded 10 coumarins (esculetin, esculin, scopolin, isoscopolin, daphnetin, umbelliferone, 7-methoxy coumarin, scoparone, scopoletin, 6-methoxy Artemicapin C), 8 flavonoids (hyperoside, quercetin, isorhamnetin, cirsilineol, arcapillin, isorhamnetin 3-robinobioside, linarin, isorhamnetin 3-glucoiside), 6 phenolic compounds (1,5-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid methyl ester, 4,5-dicaffeoylquinic acid, 3-caffeoylquinic acid), and one chromone (capillarisin). Among these compounds, esculetin, scopoletin, quercetin, hyperoside, isorhamnetin, 3,5-dicaffeoylquinic acid methyl ester, 3,4-dicaffeoylquinic acid, and 1,5-dicaffeoylquinic acid exhibited potent alpha-glucosidase inhibitory activity when compared to the positive control acarbose. In addition, esculetin and 6-methoxy Artemicapin C displayed PTP1B inhibitory activity. Interestingly, all isolated dicaffeoylquinic acids showed significant PTP1B inhibitory activity. Therefore, the results of the present study clearly demonstrate the potential of the A. capillaris extract to inhibit alpha-glucosidase and PTP1B. These inhibitory properties can be largely attributed to a combination of different chemical structures, including coumarins, flavonoids, and dicaffeoylquinic acids, which could be further explored to develop therapeutic or preventive agents for the treatment of diabetes.
Phytochemical constituents from the herba of Artemisia apiacea.[Pubmed:12135098]
Arch Pharm Res. 2002 Jun;25(3):285-8.
Four compounds of a coumarin, a steroid and two flavonoids were isolated from the herba of Artemisia apiacea by open column chromatography. Their structures were elucidated as Artemicapin C, apigenin, daucosterol and cacticin by chemical and spectroscopic analysis. This is the first report of the isolation of these compounds from this plant.
