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Antibiotic AB 4063B

CAS# 160041-33-8

Antibiotic AB 4063B

Catalog No. BCN1827----Order now to get a substantial discount!

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Quality Control of Antibiotic AB 4063B

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Chemical structure

Antibiotic AB 4063B

3D structure

Chemical Properties of Antibiotic AB 4063B

Cas No. 160041-33-8 SDF Download SDF
PubChem ID 134715053 Appearance Powder
Formula C26H39NO3 M.Wt 413.6
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3Z)-3-[[2-[(E)-but-2-en-2-yl]-3,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-hydroxymethylidene]-1-methyl-5-propan-2-ylpyrrolidine-2,4-dione
SMILES CC=C(C)C1C(C2C(CC(CC2C=C1C)C)C)C(=C3C(=O)C(N(C3=O)C)C(C)C)O
Standard InChIKey QWNWSWFYCDLGIB-GHRZEMQSSA-N
Standard InChI InChI=1S/C26H39NO3/c1-9-15(5)19-17(7)12-18-11-14(4)10-16(6)20(18)21(19)24(28)22-25(29)23(13(2)3)27(8)26(22)30/h9,12-14,16,18-21,23,28H,10-11H2,1-8H3/b15-9+,24-22-
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Antibiotic AB 4063B

The Sclerophoma pythiophila

Biological Activity of Antibiotic AB 4063B

Description1. Antibiotic AB 4063B is active against phytopathogenic fungi.
TargetsAntifection

Antibiotic AB 4063B Dilution Calculator

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Antibiotic AB 4063B Molarity Calculator

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Preparing Stock Solutions of Antibiotic AB 4063B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4178 mL 12.089 mL 24.1779 mL 48.3559 mL 60.4449 mL
5 mM 0.4836 mL 2.4178 mL 4.8356 mL 9.6712 mL 12.089 mL
10 mM 0.2418 mL 1.2089 mL 2.4178 mL 4.8356 mL 6.0445 mL
50 mM 0.0484 mL 0.2418 mL 0.4836 mL 0.9671 mL 1.2089 mL
100 mM 0.0242 mL 0.1209 mL 0.2418 mL 0.4836 mL 0.6044 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Antibiotic AB 4063B

Electronic structure calculations on the thiazole-containing antibiotic thiostrepton: molecular mechanics, semi-empirical and ab initio analyses.[Pubmed:15713409]

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1471-4.

Thiostrepton is a highly complex cyclic thiazoyl peptide antibiotic and is active against Gram-positive bacteria. Molecular mechanics, semi-empirical and ab initio studies were utilized to further understand the structural and electronic properties of this antibiotic.

Safety evaluation of AB-LIFE((R)) (Lactobacillus plantarum CECT 7527, 7528 and 7529): Antibiotic resistance and 90-day repeated-dose study in rats.[Pubmed:27016492]

Food Chem Toxicol. 2016 Jun;92:117-28.

AB-LIFE((R)) is a probiotic product consisting of equal parts of three strains of Lactobacillus plantarum (CECT 7527, 7528, and 7529) blended with inert excipients. Whole genome sequencing was performed on each of the three strains. Antibiotic resistance was evaluated by genomic mining for resistance genes, and assessment for transferability. No risk of transfer potential was identified for any antibiotic resistance genes in the three strains. AB-LIFE((R)) was evaluated for potential subchronic oral toxicity in rats, with dosages of 300 and 1000 mg/kg BW/day (equivalent to 5.55 x 10(10) and 1.85 x 10(11) CFU/kg BW/day). Survival of the three test strains through the gastrointestinal tract was supported by fecal analysis. No adverse effects were identified with respect to in-life parameters, clinical or anatomic pathology, translocation, or fecal chemical analyses. The no-observed-adverse-effect level (NOAEL) for AB-LIFE((R)) in male and female rats was 1000 mg/kg BW/day (1.85 x 10(11) CFU of AB-LIFE((R))/kg BW/day), the highest dose level evaluated. These results, in conjunction with a previous acute toxicity study in rats, support the conclusion that AB-LIFE((R)) is safe for human consumption.

Studies aimed at the total synthesis of the antitumor antibiotic cochleamycin A. An enantioselective biosynthesis-based pathway to the AB bicyclic core.[Pubmed:11796063]

Org Lett. 2002 Jan 24;4(2):253-6.

[reaction: see text] A convergent, highly enantioselective synthesis of the fully functionalized AB sector of cochleamycin A is described. A pair of building blocks, crafted from L-malic and L-ascorbic acids, are conjoined in a manner that gives rise to an (E,Z,E)-1,6,8-nonatriene. On heating, the latter undergoes stereocontrolled intramolecular Diels-Alder cyclization via an endo transition state.

A cluster randomized trial for the implementation of an antibiotic checklist based on validated quality indicators: the AB-checklist.[Pubmed:25888180]

BMC Infect Dis. 2015 Mar 19;15:134.

BACKGROUND: Recently we developed and validated generic quality indicators that define 'appropriate antibiotic use' in hospitalized adults treated for a (suspected) bacterial infection. Previous studies have shown that with appropriate antibiotic use a reduction of 13% of length of hospital stay can be achieved. Our main objective in this project is to provide hospitals with an antibiotic checklist based on these quality indicators, and to evaluate the introduction of this checklist in terms of (cost-) effectiveness. METHODS/DESIGN: The checklist applies to hospitalized adults with a suspected bacterial infection for whom antibiotic therapy is initiated, at first via the intravenous route. A stepped wedge study design will be used, comparing outcomes before and after introduction of the checklist in nine hospitals in the Netherlands. At least 810 patients will be included in both the control and the intervention group. The primary endpoint is length of hospital stay. Secondary endpoints are appropriate antibiotic use measured by the quality indicators, admission to and duration of intensive care unit stay, readmission within 30 days, mortality, total antibiotic use, and costs associated with implementation and hospital stay. Differences in numerical endpoints between the two periods will be evaluated with mixed linear models; for dichotomous outcomes generalized estimating equation models will be used. A process evaluation will be performed to evaluate the professionals' compliance with use of the checklist. The key question for the economic evaluation is whether the benefits of the checklist, which include reduced antibiotic use, reduced length of stay and associated costs, justify the costs associated with implementation activities as well as daily use of the checklist. DISCUSSION: If (cost-) effective, the AB-checklist will provide physicians with a tool to support appropriate antibiotic use in adult hospitalized patients who start with intravenous antibiotics. TRIAL REGISTRATION: Dutch trial registry: NTR4872.

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