Anethole trithioneCAS# 532-11-6 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 532-11-6 | SDF | Download SDF |
| PubChem ID | 2194 | Appearance | Orange red crystal |
| Formula | C10H8Os3 | M.Wt | 698.9 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 100 mg/mL (416.04 mM; Need ultrasonic) | ||
| Chemical Name | 5-(4-methoxyphenyl)dithiole-3-thione | ||
| SMILES | COC1=CC=C(C=C1)C2=CC(=S)SS2 | ||
| Standard InChIKey | KYLIZBIRMBGUOP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H8OS3/c1-11-8-4-2-7(3-5-8)9-6-10(12)14-13-9/h2-6H,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Anethole trithione Dilution Calculator
Anethole trithione Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4308 mL | 7.1541 mL | 14.3082 mL | 28.6164 mL | 35.7705 mL |
| 5 mM | 0.2862 mL | 1.4308 mL | 2.8616 mL | 5.7233 mL | 7.1541 mL |
| 10 mM | 0.1431 mL | 0.7154 mL | 1.4308 mL | 2.8616 mL | 3.577 mL |
| 50 mM | 0.0286 mL | 0.1431 mL | 0.2862 mL | 0.5723 mL | 0.7154 mL |
| 100 mM | 0.0143 mL | 0.0715 mL | 0.1431 mL | 0.2862 mL | 0.3577 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Anethole trithione is a drug used in the treatment of dry mouth， being studied in the treatment of cancer.
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An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione.[Pubmed:21766311]
J Pharm Sci. 2011 Nov;100(11):5048-58.
In this study, an examination of the potential effect of lipids on the first-pass metabolism of anethol trithione (ATT) was investigated. ATT is metabolized rapidly and extensively in liver into 4-hydroxy-Anethole trithione (ATX), which was confirmed using the rat intestinal perfusion with the mesenteric cannulation model. Male Sprague-Dawley rats were orally administered of the lipid-based formulations (prepared by medium chain triglycerides (MCT)), the cyclodextrin formulation and the suspension formulation, respectively. For 6.75 mg/kg groups, ATX/ATT area under the plasma concentration-time curve (AUC) ratio decreased by 87% and 76% after administration of the MCT-based formulations and the cyclodextrin formulation, when compared with the suspension formulation (p < 0.05), respectively; for 2.25 mg/kg groups, it decreased by 53% in the MCT group when compared with the cyclodextrin group (p < 0.05). The saturation of pre-system metabolism of ATT was observed after administration of the MCT-based formulations and the cyclodextrin formulation, likely as a result of enhanced absorption and therefore presentation of higher drug concentrations to liver, when compared with the suspension formulation. A trend toward lower systemic metabolite to parent ratios was evident after administration of the lipid formulations, when compared with the cyclodextrin formulation; however, this was not statistically significant. Further studies on the potential for lipids to inhibit hepatic metabolism are therefore warranted.
Quantitative morphometry of respiratory tract epithelial cells as a tool for testing chemopreventive agent efficacy.[Pubmed:20392991]
Anticancer Res. 2010 Mar;30(3):737-42.
Previously, we developed a 30-day transformation assay (focus inhibition, FIA) of rat tracheal epithelial (RTE) cells to identify cancer preventive agents. This study reports nuclear density (ND) as a morphometric biomarker for efficacy evaluation of at an early stage before transformed foci appear. Positive (oltipraz, D-carvone, fumaric acid, and 2-amino-4-methylpyridine or 2-A-MPR) and negative agents (myristoleic acid, Anethole trithione, hydrocortisone, and 3'-hydroxyflavanone), identified from FIA, were tested for their effect on ND. RTE cells plated for 24 h were treated with a carcinogen, benzo[a] pyrene (B[a]P) or plus a test agent. The data based on the number of nuclei in agent-treated and control cells at day 14 showed that all FIA-positive agents inhibited ND from 23-66% at 0.3-1000.0 microM and except for myristoleic acid, all of the FIA-negative compounds were also negative in the morphometry assay. As there is strong correlation between the FIA and morphometry data, morphometry analysis is useful for rapid screening of potential chemopreventive agents.
An HPLC-MS/MS method for the quantitative determination of 4-hydroxy-anethole trithione in human plasma and its application to a pharmacokinetic study.[Pubmed:20980118]
J Pharm Biomed Anal. 2011 Feb 20;54(3):551-6.
A selective, rapid and sensitive method for the quantitation of 4-hydroxy-Anethole trithione (ATX) in human plasma based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed and validated. Paracetamol was used as the internal standard (I.S.). After liquid-liquid extraction of 500 muL plasma with ethyl acetate, ATX and the I.S. were chromatographed on an Inertsil((R)) ODS-3 column. The mobile phase was consisted of methanol-water (75:25, v/v) with a flow rate of 0.25 mL/min. The detection was performed on a triple quadrupole tandem mass spectrometer by multiple reaction monitoring (MRM) mode via electrospray ionization (ESI) source. The calibration curve was linear over the range of 0.452-603 ng/mL (r(2)>/=0.99) with a lower limit of quantitation (LLOQ) of 0.452 ng/mL. The intra- and inter-day precision (relative standard deviation, R.S.D.) values were below 13% and the accuracy (relative error, R.E.) was from -2.7% to -7.5% at three quality control levels. The assay herein described was successfully applied to a pharmacokinetic study of Anethole trithione (ATT) tablet in healthy volunteers after oral administration.
