Agrimonolide

CAS# 21499-24-1

Agrimonolide

Catalog No. BCN4925----Order now to get a substantial discount!

Product Name & Size Price Stock
Agrimonolide:5mg Please Inquire In Stock
Agrimonolide:10mg Please Inquire In Stock
Agrimonolide:20mg Please Inquire In Stock
Agrimonolide:50mg Please Inquire In Stock

Quality Control of Agrimonolide

Number of papers citing our products

Chemical structure

Agrimonolide

3D structure

Chemical Properties of Agrimonolide

Cas No. 21499-24-1 SDF Download SDF
PubChem ID 161362 Appearance Powder
Formula C18H18O5 M.Wt 314.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3S)-6,8-dihydroxy-3-[2-(4-methoxyphenyl)ethyl]-3,4-dihydroisochromen-1-one
SMILES COC1=CC=C(C=C1)CCC2CC3=CC(=CC(=C3C(=O)O2)O)O
Standard InChIKey TYFJTEPDESMEHE-HNNXBMFYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Agrimonolide

The herb of Agrimonia pilosa Ledeb.

Biological Activity of Agrimonolide

Description1. Agrimonolide exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 MAPKs signaling pathway. 2. Agrimonolide is a potential α1 adrenergic receptor antagonist . 3. Agrimonolide and desmethylagrimonolide can effectively increase insulin-mediated glycogen level in heptocytes, they may play an important role in regulating glucose metabolism in insulin-resistance HepG2 cells and could be developed as a promising natural material for diabetes prevention and treatment.
TargetsTNF-α | NO | NOS | COX | JNK | p38MAPK | JAK | STAT | NF-kB | IL Receptor | Adrenergic Receptor

Agrimonolide Dilution Calculator

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Agrimonolide Molarity Calculator

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Preparing Stock Solutions of Agrimonolide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Agrimonolide

Preparative purification of five bioactive components from Agrimonia pilosa Ledeb by high-speed counter-current chromatography.[Pubmed:22865760]

J Sep Sci. 2012 Aug;35(15):1977-84.

High-speed counter-current chromatography (HSCCC) coupled with ultraviolet (UV) detection or evaporative light-scattering detection was successfully applied for preparative separation of five bioactive compounds from Agrimonia pilosa Ledeb. In preliminary process, D101 macroporous resin was used to separate the crude extract of the plant and four fractions (20, 40, 50, and 60% aqueous ethanol elutions) were produced. Then, these fractions were directly subjected to HSCCC purification. Five chemicals including taxifolin-3-glucoside (6.4 mg), quercetin-3-rhamnoside (13.0 mg), tiliroside (14.7 mg), Agrimonolide (21.4 mg), and tormentic acid (29.8 mg) with the purities of 94.24, 95.37, 97.42, 95.29, and 96.34% were separated from each 200 mg prepared fraction. The purities were analyzed by high-performance liquid chromatography, and the chemical structures of the products were identified by UV detection, mass spectrometry, nuclear magnetic resonance, and the standards. This paper used a simple method to separate five bioactive compounds from A. pilosa Ledeb, and it could provide a new idea for the purification of bioactive compounds from other medicinal plants.

Agrimonolide from Agrimonia pilosa suppresses inflammatory responses through down-regulation of COX-2/iNOS and inactivation of NF-kappaB in lipopolysaccharide-stimulated macrophages.[Pubmed:27288920]

Phytomedicine. 2016 Jul 15;23(8):846-55.

BACKGROUND: Agrimonolide from Agrimonia pilosa showed a strong anti-inflammatory activity, and the present study aims to reveal potential mechanisms on molecular level explaining its anti-inflammatory effect. HYPOTHESIS/PURPOSE: To investigate the mechanism of anti-inflammatory activity of Agrimonolide. STUDY DESIGN: Anti-inflammatory activity of Agrimonolide in cells was applied. METHODS: Anti-inflammatory activity of Agrimonolide isolated from Agrimonia pilosa was evaluated using lipopolysaccharide (LPS) stimulated RAW 264.7 cell models. The productions of IL-1beta, IL-6, TNF-alpha and NO were determined by ELISA and nitrite analysis, respectively. The expressions of iNOS and COX-2 were measured by western blotting and RT-PCR analysis. RESULTS: The pre-treatment with Agrimonolide significantly reduced the levels of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), as well as attenuated the expression of iNOS and COX-2 in LPS-stimulated macrophages. Furthermore, Agrimonolide inhibited the activation of JNK and p38 MAPKs and decreased the activation of JAK-STAT and NF-kappaB in LPS-stimulated macrophages. CONCLUSION: The present study suggested that Agrimonolide exerted anti- inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 MAPKs signaling pathway.

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