Aeruginolactone

CAS# 1005208-88-7

Aeruginolactone

Catalog No. BCN3695----Order now to get a substantial discount!

Product Name & Size Price Stock
Aeruginolactone:5mg Please Inquire In Stock
Aeruginolactone:10mg Please Inquire In Stock
Aeruginolactone:20mg Please Inquire In Stock
Aeruginolactone:50mg Please Inquire In Stock

Quality Control of Aeruginolactone

Number of papers citing our products

Chemical structure

Aeruginolactone

3D structure

Chemical Properties of Aeruginolactone

Cas No. 1005208-88-7 SDF Download SDF
PubChem ID 102004678 Appearance Powder
Formula C15H20O3 M.Wt 248.3
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (5E,9E)-11a-hydroxy-3,6,10-trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan-2-one
SMILES CC1=CCC2=C(C(=O)OC2(CC(=CCC1)C)O)C
Standard InChIKey RNKGNLZCXUOTKL-NXAIOARDSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Aeruginolactone

The rhizomes of Curcuma rcenyujin Y,H. Chenet C.Ling

Biological Activity of Aeruginolactone

DescriptionStandard reference
In vitro

Characterization of in vivo and in vitro metabolites of furanodiene in rats by high performance liquid chromatography-electrospray ionization mass spectrometry and nuclear magnetic resonance spectra.[Pubmed: 23998967]

J Pharm Biomed Anal. 2013 Dec;86:161-8.


METHODS AND RESULTS:
All of these metabolites were phase I metabolites, with three new compounds including 2β-hydroxyl-Aeruginolactone (2), 14-hydroxyl-Aeruginolactone (3), 1β,8β-dihydroxyeudesm-4,7(11)-dien-8α,12-olide (4a), and four known compounds, 1β,10α,4α,5β-diepoxy-8α-hydroxy-glechoman-8α,12-olide (1), 1β,8β-dihydroxyeudesm-4(14),7(11)-dien-8α,12-olide (4b), 1β,8β-dihydroxyeudesm-3,7(11)-dien-8α,12-olide (5) and Aeruginolactone (6). Interestingly, the metabolite 6 was found to be a primary metabolite in urine, bile and feces. All metabolites were found to be both in urine and bile but only few metabolites except the metabolite 6 presented in feces after oral dose of furanodiene to rats. Furthermore, the metabolic pathways of furanodiene were proposed using an in vitro assay by incubation of furanodiene and its metabolites in vivo with rat liver S9 or liver microsomes.
CONCLUSIONS:
Clearly, Aeruginolactone (6) seemed to be a major precursor for other metabolites.

Aeruginolactone Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Aeruginolactone Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Aeruginolactone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.0274 mL 20.1369 mL 40.2739 mL 80.5477 mL 100.6847 mL
5 mM 0.8055 mL 4.0274 mL 8.0548 mL 16.1095 mL 20.1369 mL
10 mM 0.4027 mL 2.0137 mL 4.0274 mL 8.0548 mL 10.0685 mL
50 mM 0.0805 mL 0.4027 mL 0.8055 mL 1.611 mL 2.0137 mL
100 mM 0.0403 mL 0.2014 mL 0.4027 mL 0.8055 mL 1.0068 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Aeruginolactone

Characterization of in vivo and in vitro metabolites of furanodiene in rats by high performance liquid chromatography-electrospray ionization mass spectrometry and nuclear magnetic resonance spectra.[Pubmed:23998967]

J Pharm Biomed Anal. 2013 Dec;86:161-8.

Furanodiene is an active ingredient of Rhizoma Curcumae, a very famous Traditional Chinese Medicine (TCM) widely used for the treatment of cancer. Although the anti-tumor effect of furanodiene has well been established, its metabolic profile in vivo and in vitro is still unclear. In the present study, the metabolites of furanodiene in rats were studied. After oral administration of furanodiene, the rats' urine, feces and bile were collected and produced seven metabolites by the use of macroporous adsorption resin chromatography, and semi-preparative high performance liquid chromatography. Their structures were identified by mass spectrometry and NMR data including (1)H, (13)C, and two-dimensional NMR data. All of these metabolites were phase I metabolites, with three new compounds including 2beta-hydroxyl-Aeruginolactone (2), 14-hydroxyl-Aeruginolactone (3), 1beta,8beta-dihydroxyeudesm-4,7(11)-dien-8alpha,12-olide (4a), and four known compounds, 1beta,10alpha,4alpha,5beta-diepoxy-8alpha-hydroxy-glechoman-8alpha,12-olide (1), 1beta,8beta-dihydroxyeudesm-4(14),7(11)-dien-8alpha,12-olide (4b), 1beta,8beta-dihydroxyeudesm-3,7(11)-dien-8alpha,12-olide (5) and Aeruginolactone (6). Interestingly, the metabolite 6 was found to be a primary metabolite in urine, bile and feces. All metabolites were found to be both in urine and bile but only few metabolites except the metabolite 6 presented in feces after oral dose of furanodiene to rats. Furthermore, the metabolic pathways of furanodiene were proposed using an in vitro assay by incubation of furanodiene and its metabolites in vivo with rat liver S9 or liver microsomes. Clearly, Aeruginolactone (6) seemed to be a major precursor for other metabolites.

Keywords:

Aeruginolactone,1005208-88-7,Natural Products, buy Aeruginolactone , Aeruginolactone supplier , purchase Aeruginolactone , Aeruginolactone cost , Aeruginolactone manufacturer , order Aeruginolactone , high purity Aeruginolactone

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: