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5,7,4'-Trihydroxy-8-methylflavanone

CAS# 916917-28-7

5,7,4'-Trihydroxy-8-methylflavanone

Catalog No. BCN2844----Order now to get a substantial discount!

Product Name & Size Price Stock
5,7,4'-Trihydroxy-8-methylflavanone:5mg Please Inquire In Stock
5,7,4'-Trihydroxy-8-methylflavanone:10mg Please Inquire In Stock
5,7,4'-Trihydroxy-8-methylflavanone:20mg Please Inquire In Stock
5,7,4'-Trihydroxy-8-methylflavanone:50mg Please Inquire In Stock

Quality Control of 5,7,4'-Trihydroxy-8-methylflavanone

Number of papers citing our products

Chemical structure

5,7,4'-Trihydroxy-8-methylflavanone

3D structure

Chemical Properties of 5,7,4'-Trihydroxy-8-methylflavanone

Cas No. 916917-28-7 SDF Download SDF
PubChem ID 16094542 Appearance Powder
Formula C16H14O5 M.Wt 286.08
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-methyl-2,3-dihydrochromen-4-one
SMILES CC1=C(C=C(C2=C1OC(CC2=O)C3=CC=C(C=C3)O)O)O
Standard InChIKey GMVYLXBMPRDZDR-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 5,7,4'-Trihydroxy-8-methylflavanone

The herbs of Scutellaria indica L.

Biological Activity of 5,7,4'-Trihydroxy-8-methylflavanone

In vitro

Chemical constituents from Rhododendron spiciferum and their effects on immunocyte of mice.[Reference: WebLink]

Chinese Traditional & Herbal Drugs, 2010 , 41 (1) :19-23.

To study the chemical constituents from the leaves of Rhododendron spiciferum and their immunomodulatory activities.
METHODS AND RESULTS:
The chemical constituents were isolated by various chromatography techniques and their structures were elucidated on the basis of spectroscopic data. The immunomodulatory activity of some compounds was examined by Balb/c mouse spleen lymphocyte proliferation through MTT. Twelve known flavonoids were isolated and identified as: quercetin-3-O-α-L-ara-binfuranside (1), quercetin-3-O-α-L-rhamnopyranoside (2), trans-taxifolin-3-O-α- arabinopyranoside (3), astilbin (4), 3-Orhamnoside engeletin (5), naringenin (6), (2S)-5,7,4'-Trihydroxy-8-methylflavanone (7), epicatechin- (2β→O→7,4β→8)-ent-epicatechin (8), proanthocyanidin A-l (9), bis-8, 8′-catechiny-lmethane (10), catechin (11), and epicatechin (12). The results showed that compounds 8, 9, and 11 alone or combined with ConA or LPS could significantly enhance the proliferation of spleen lymphocytes in a certain dose range.
CONCLUSIONS:
This is the first report on the chemical constituents from R. spiciferum. Compounds 8,9, and 11 are found to be effect on increasing immunomodulatory activity.

5,7,4'-Trihydroxy-8-methylflavanone Dilution Calculator

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5,7,4'-Trihydroxy-8-methylflavanone Molarity Calculator

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Preparing Stock Solutions of 5,7,4'-Trihydroxy-8-methylflavanone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4955 mL 17.4776 mL 34.9553 mL 69.9105 mL 87.3881 mL
5 mM 0.6991 mL 3.4955 mL 6.9911 mL 13.9821 mL 17.4776 mL
10 mM 0.3496 mL 1.7478 mL 3.4955 mL 6.9911 mL 8.7388 mL
50 mM 0.0699 mL 0.3496 mL 0.6991 mL 1.3982 mL 1.7478 mL
100 mM 0.035 mL 0.1748 mL 0.3496 mL 0.6991 mL 0.8739 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5,7,4'-Trihydroxy-8-methylflavanone

Chemical constituents from Rhododendron spiciferum and their effects on immunocyte of mice.

Chinese Traditional & Herbal Drugs, 2010 , 41 (1) :19-23.

To study the chemical constituents from the leaves of Rhododendron spiciferum and their immunomodulatory activities. Methods The chemical constituents were isolated by various chromatography techniques and their structures were elucidated on the basis of spectroscopic data. The immunomodulatory activity of some compounds was examined by Balb/c mouse spleen lymphocyte proliferation through MTT. Results Twelve known flavonoids were isolated and identified as: quercetin-3-O-α-L-ara-binfuranside (1), quercetin-3-O-α-L-rhamnopyranoside (2), trans-taxifolin-3-O-α- arabinopyranoside (3), astilbin (4), 3-Orhamnoside engeletin (5), naringenin (6), (2S)-5,7,4'-Trihydroxy-8-methylflavanone (7), epicatechin- (2β→O→7,4β→8)-ent-epicatechin (8), proanthocyanidin A-l (9), bis-8, 8′-catechiny-lmethane (10), catechin (11), and epicatechin (12). The results showed that compounds 8, 9, and 11 alone or combined with ConA or LPS could significantly enhance the proliferation of spleen lymphocytes in a certain dose range. Conclusion This is the first report on the chemical constituents from R. spiciferum. Compounds 8,9, and 11 are found to be effect on increasing immunomodulatory activity.

Description

5,7,4'-Trihydroxy-8-Methylflavanone (Compound 2) is a flavanone isolated from Qualea grandiflora.

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