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3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol

CAS# 466663-12-7

3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol

Catalog No. BCN1437----Order now to get a substantial discount!

Product Name & Size Price Stock
3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol:5mg Please Inquire In Stock
3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol:10mg Please Inquire In Stock
3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol:20mg Please Inquire In Stock
3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol:50mg Please Inquire In Stock
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Quality Control of 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol

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Chemical structure

3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol

3D structure

Chemical Properties of 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol

Cas No. 466663-12-7 SDF Download SDF
PubChem ID 102004598 Appearance Powder
Formula C32H44O7 M.Wt 540.7
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CCCCCC=CC=CC(=O)OC1C(=CC23C1(C(C(=CC(C2=O)C4C(C4(C)C)CC3C)COC(=O)C)O)O)C
Standard InChIKey SYXKKJDQNXPUSI-OJHJWTESSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol

The roots of Euphorbia kansui T. N. Liou ex S. B. Ho

Biological Activity of 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol

Description1. 3-O-(2′E,4′E-decadienoyl)-20-O-acetylingenol has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships.

3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol Dilution Calculator

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3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol Molarity Calculator

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Preparing Stock Solutions of 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8495 mL 9.2473 mL 18.4945 mL 36.9891 mL 46.2364 mL
5 mM 0.3699 mL 1.8495 mL 3.6989 mL 7.3978 mL 9.2473 mL
10 mM 0.1849 mL 0.9247 mL 1.8495 mL 3.6989 mL 4.6236 mL
50 mM 0.037 mL 0.1849 mL 0.3699 mL 0.7398 mL 0.9247 mL
100 mM 0.0185 mL 0.0925 mL 0.1849 mL 0.3699 mL 0.4624 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol

Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1.[Pubmed:23109850]

Int J Mol Sci. 2012;13(9):11247-59.

The dried roots of Euphorbia kansui (kansui) have been used for centuries in China as a herbal medicine for edema, ascites, and asthma. The 95% ethanol extract showed a significant inhibition of cell proliferation against human normal cell lines L-O2 and GES-1. Bioassay-guided separation of the 95% ethanol extract from the roots of E. kansui led to the isolation of 12 diverse terpenoids whose structures were identified by (1)H, (13)C NMR spectroscopy and ESI-MS as kansuinine A (1), kansuinine B (2), kansuinine C (3), kansuiphorin C (4), 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol (5), 3-O-(2'E,4'Edecadienoyl)-20-O-acetylingenol (6), 3-O-(2'E,4'Z-decadienoyl)-20-deoxyingenol (7), 3-O-benzoyl-20-deoxyingenol (8), 5-O-benzoyl-20-deoxyingenol (9), kansenone (10), epi-kansenone (11), euphol (12). All these 12 terpernoids were evaluated in vitro for cytotoxicity on L-O2 and GES-1 cell lines. Most ingenane-type diterpenoids and 8-ene-7-one triterpenoids (5-11) exhibited a relatively lower IC(50) value; therefore, these compounds had stronger cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships. These results will be significantly helpful to reveal the mechanism of toxicity of kansui and to effectively guide safer clinical application of this herb.

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