2-Hydroxycinnamic acidCAS# 614-60-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 614-60-8 | SDF | Download SDF |
| PubChem ID | 637540 | Appearance | Beige powder |
| Formula | C9H8O3 | M.Wt | 164.16 |
| Type of Compound | Phenylpropanoids | Storage | Desiccate at -20°C |
| Synonyms | trans-2-Hydroxycinnamic acid; (E)-3-(2-Hydroxyphenyl)acrylic acid | ||
| Solubility | Soluble in ethanol and methanol; slightly soluble in water | ||
| Chemical Name | (E)-3-(2-hydroxyphenyl)prop-2-enoic acid | ||
| SMILES | C1=CC=C(C(=C1)C=CC(=O)O)O | ||
| Standard InChIKey | PMOWTIHVNWZYFI-AATRIKPKSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 2-Hydroxycinnamic acid has photooxidant activity; 2-hydroxycinnamic acid germanium has strong inhibitory effect on the tumor U14; trans-2-hydroxycinnamic acid has efficacy against trichlorfon-induced oxidative stress in wistar rats. |
| Targets | SOD | LPO |
| In vivo | Efficacy of trans-2-hydroxycinnamic Acid against trichlorfon-induced oxidative stress in wistar rats.[Pubmed: 23293469]Toxicol Int. 2012 Sep;19(3):295-300.Trichlorfon is an organophosphate insecticide used to control cockroaches, crickets, silverfish, bedbugs, fleas, cattle grubs, flies, ticks, leaf miners, and leaf-hoppers. It is also used to treat domestic animals for control of internal parasites. Trans-2-Hydroxycinnamic acid (T2HCA) is a hydroxyl derivative of cinnamic acid. The present study highlights trichlorofon-induced toxicity and the protective role of T2HCA in the liver, kidney, and brain of female Wistar rats. |
| Animal Research | The inhibitory effect of 2-hydroxycinnamic acid germanium on the tumor U14.[Reference: WebLink]Northwest Pharmaceutical Journal, 2010, 25(6):438-9.To observe the inhibitory effect of 2-Hydroxycinnamic acid germanium on the tumor U14. |
2-Hydroxycinnamic acid Dilution Calculator
2-Hydroxycinnamic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.0916 mL | 30.4581 mL | 60.9162 mL | 121.8324 mL | 152.2904 mL |
| 5 mM | 1.2183 mL | 6.0916 mL | 12.1832 mL | 24.3665 mL | 30.4581 mL |
| 10 mM | 0.6092 mL | 3.0458 mL | 6.0916 mL | 12.1832 mL | 15.229 mL |
| 50 mM | 0.1218 mL | 0.6092 mL | 1.2183 mL | 2.4366 mL | 3.0458 mL |
| 100 mM | 0.0609 mL | 0.3046 mL | 0.6092 mL | 1.2183 mL | 1.5229 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Efficacy of trans-2-hydroxycinnamic Acid against trichlorfon-induced oxidative stress in wistar rats.[Pubmed:23293469]
Toxicol Int. 2012 Sep;19(3):295-300.
Trichlorfon is an organophosphate insecticide used to control cockroaches, crickets, silverfish, bedbugs, fleas, cattle grubs, flies, ticks, leaf miners, and leaf-hoppers. It is also used to treat domestic animals for control of internal parasites. Trans-2-Hydroxycinnamic acid (T2HCA) is a hydroxyl derivative of cinnamic acid. The present study highlights trichlorofon-induced toxicity and the protective role of T2HCA in the liver, kidney, and brain of female Wistar rats. The rats were given a single dose of trichlorofon (150 mg / kg bw) and pre- and post-treatment T2HCA (50 mg / kg bw) for seven days. Trichlorofon enhanced oxidative stress in liver, kidney, and brain of the rats, which was evident from the elevation of lipid peroxidation (LPO). The reduced level of non-enzymatic antioxidant glutathione (GSH) also indicated the presence of an oxidative insult. The activity of enzymatic antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx) was significantly decreased on trichlorfon administration. Pre and post treatment with T2HCA decreased the LPO level and increased SOD, CAT, GST, GR, GPx, and GSH in the brain, liver, and kidney. Trichlorfon-induced reduction in acelylcholinestrase was also ameliorated with T2HCA treatment. In conclusion, trichlorfon-mediated induction in the reactive oxygen species and disturbance in the antioxidant enzymes' defense system was moderately ameliorated by antioxidant trans-2-Hydroxycinnamic acid.
