16-Oxocleroda-3,13E-dien-15-oic acidCAS# 117620-72-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 117620-72-1 | SDF | Download SDF |
| PubChem ID | 38355304 | Appearance | Powder |
| Formula | C20H30O3 | M.Wt | 318.45 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E)-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-formylpent-2-enoic acid | ||
| SMILES | CC1CCC2(C(C1(C)CCC(=CC(=O)O)C=O)CCC=C2C)C | ||
| Standard InChIKey | LUZARHTWSOXFLP-HEZUFYQYSA-N | ||
| Standard InChI | InChI=1S/C20H30O3/c1-14-6-5-7-17-19(14,3)10-8-15(2)20(17,4)11-9-16(13-21)12-18(22)23/h6,12-13,15,17H,5,7-11H2,1-4H3,(H,22,23)/b16-12+/t15-,17+,19+,20+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 16-Oxocleroda-3,13E-dien-15-oic acid shows antiplasmodial activity. |
| Targets | Antifection |
16-Oxocleroda-3,13E-dien-15-oic acid Dilution Calculator
16-Oxocleroda-3,13E-dien-15-oic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1402 mL | 15.7011 mL | 31.4021 mL | 62.8042 mL | 78.5053 mL |
| 5 mM | 0.628 mL | 3.1402 mL | 6.2804 mL | 12.5608 mL | 15.7011 mL |
| 10 mM | 0.314 mL | 1.5701 mL | 3.1402 mL | 6.2804 mL | 7.8505 mL |
| 50 mM | 0.0628 mL | 0.314 mL | 0.628 mL | 1.2561 mL | 1.5701 mL |
| 100 mM | 0.0314 mL | 0.157 mL | 0.314 mL | 0.628 mL | 0.7851 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one
Catalog No.:BCN1607
CAS No.:117614-84-3
- 6-Hydroxymethylherniarin
Catalog No.:BCN3573
CAS No.:117597-79-2
- Coronarin E
Catalog No.:BCN6052
CAS No.:117591-81-8
- Calpeptin
Catalog No.:BCC2351
CAS No.:117591-20-5
- DMXAA (Vadimezan)
Catalog No.:BCC3644
CAS No.:117570-53-3
- threo-6'-Hydroxyustusolate C
Catalog No.:BCN6930
CAS No.:1175543-07-3
- Ustusolate E
Catalog No.:BCN7789
CAS No.:1175543-06-2
- 2alpha,9alpha,11-Trihydroxy-6-oxodrim-7-ene
Catalog No.:BCN7741
CAS No.:1175543-03-9
- Ustusol A
Catalog No.:BCN7719
CAS No.:1175543-02-8
- Neuromedin U (rat)
Catalog No.:BCC5847
CAS No.:117505-80-3
- ROX NHS ester, pure 6- isomer
Catalog No.:BCC3587
CAS No.:117491-83-5
- Sesamoside
Catalog No.:BCN6051
CAS No.:117479-87-5
- 3-Cyano-7-ethoxycoumarin
Catalog No.:BCC7979
CAS No.:117620-77-6
- Agomelatine hydrochloride
Catalog No.:BCC4210
CAS No.:1176316-99-6
- LY 255283
Catalog No.:BCC7290
CAS No.:117690-79-6
- DL-Syringaresinol
Catalog No.:BCN6053
CAS No.:1177-14-6
- Laxogenin
Catalog No.:BCN8434
CAS No.:1177-71-5
- Dexamethasone acetate
Catalog No.:BCC4775
CAS No.:1177-87-3
- Doramectin
Catalog No.:BCC1536
CAS No.:117704-25-3
- CKI 7 dihydrochloride
Catalog No.:BCC5614
CAS No.:1177141-67-1
- (R)-(+)-Blebbistatin
Catalog No.:BCC7195
CAS No.:1177356-70-5
- Felbamate hydrate
Catalog No.:BCC4160
CAS No.:1177501-39-1
- Forsythoside I
Catalog No.:BCN6430
CAS No.:1177581-50-8
- N20C hydrochloride
Catalog No.:BCC7292
CAS No.:1177583-87-7
Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection.[Pubmed:25914039]
J Ethnopharmacol. 2015 Jul 1;169:176-82.
BACKGROUND: Plasmodium falciparum drug resistance is a major public health challenge in sub-Sahara Africa. Many people are now resorting to the use of herbs in managing malaria due to the increasing treatment failures with the conventional drugs. In this study the ethanolic extract of Polyalthia longifolia (Sonn) Thw. var. pendula, a variety fondly used in folklore medicine in Ghana was investigated for potential antimalarial drug development. METHOD: The ethanolic extract of P. longifolia (Sonn) Thw. var. pendula stem bark was screened against the multidrug resistant, K1 strain of P. falciparum by the parasite lactate dehydrogenase (pLDH) assay and a good antiplasmodial activity (IC50 22.04+/- 4.23microg/ml) was observed which led to further chromatographic analysis in search for actives. RESULTS: Bioassay guided fractionation of the extract yielded; three clerodane diterpenes [16-hydroxycleroda-3,13-dien-16,15-olide (1), 16-Oxocleroda-3,13E-dien-15-oic acid (2) and 3,16-dihydroxycleroda-4(18),13(14)Z-dien-15,16-olide (3)], a steroid [beta-stigmasterol (4)] and two alkaloids [darienine (5) and stepholidine (6)]. While compounds 4, 5 and 6 exhibited weak antiplasmodial activity (IC50 22-105microg/ml), the clerodane diterpenes exhibited significantly potent (p<0.005) blood schizonticidal activity (IC50: 3-6microg/ml). This is the first report of the antiplasmodial activity of compounds 2 and 3. In combination assay with chloroquine, compounds 1, 2, 3 and 5 antagonized the antiplasmodial activity of chloroquine while 4 and 6 demonstrated a synergistic action. CONCLUSION: The potent antiplasmodial activity of the extract of P. longifolia (Sonn) Thw. var. pendula and compounds therein strongly suggests its usefulness as an antimalarial agent and supports its inclusion or exploitation in formulations of herbal remedies for malaria in Ghana.
