5-MethoxyisatinCAS# 39755-95-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 39755-95-8 | SDF | Download SDF |
| PubChem ID | 38333 | Appearance | Powder |
| Formula | C9H7NO3 | M.Wt | 177.16 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-methoxy-1H-indole-2,3-dione | ||
| SMILES | COC1=CC2=C(C=C1)NC(=O)C2=O | ||
| Standard InChIKey | DMHGXMPXHPOXBF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C9H7NO3/c1-13-5-2-3-7-6(4-5)8(11)9(12)10-7/h2-4H,1H3,(H,10,11,12) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
5-Methoxyisatin Dilution Calculator
5-Methoxyisatin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.6446 mL | 28.2231 mL | 56.4462 mL | 112.8923 mL | 141.1154 mL |
| 5 mM | 1.1289 mL | 5.6446 mL | 11.2892 mL | 22.5785 mL | 28.2231 mL |
| 10 mM | 0.5645 mL | 2.8223 mL | 5.6446 mL | 11.2892 mL | 14.1115 mL |
| 50 mM | 0.1129 mL | 0.5645 mL | 1.1289 mL | 2.2578 mL | 2.8223 mL |
| 100 mM | 0.0564 mL | 0.2822 mL | 0.5645 mL | 1.1289 mL | 1.4112 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity.[Pubmed:28801274]
Eur J Pharm Sci. 2017 Nov 15;109:381-388.
Targeting protein aggregation for the therapy of neurodegenerative diseases remains elusive for medicinal chemists, despite a number of small molecules known to interfere in amyloidogenesis, particularly of amyloid beta (Abeta) protein. Starting from previous findings in the antiaggregating activity of a class of indolin-2-ones inhibiting Abeta fibrillization, 5-Methoxyisatin 3-(4-isopropylphenyl)hydrazone 1 was identified as a multitarget inhibitor of Abeta aggregation and cholinesterases with IC50s in the low muM range. With the aim of increasing aqueous solubility, a Mannich-base functionalization led to the synthesis of N-methylpiperazine derivative 2. At acidic pH, an outstanding solubility increase of 2 over the parent compound 1 was proved through a turbidimetric method. HPLC analysis revealed an improved stability of the Mannich base 2 at pH2 along with a rapid release of 1 in human serum as well as an outstanding hydrolytic stability of the parent hydrazone. Coincubation of Abeta1-42 with 2 resulted in the accumulation of low MW oligomers, as detected with PICUP assay. Cell assays on SH-SY5Y cells revealed that 2 exerts strong cytoprotective effects in both cell viability and radical quenching assays, mainly related to its active metabolite 1. These findings show that 2 drives the formation of non-toxic, off-pathway Abeta oligomers unable to trigger the amyloid cascade and toxicity.
