1-MethoxyphaseollidinCAS# 65428-13-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 65428-13-9 | SDF | Download SDF |
| PubChem ID | 480873 | Appearance | Powder |
| Formula | C21H22O5 | M.Wt | 354.40 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (6aR,11aR)-1-methoxy-10-(3-methylbut-2-enyl)-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromene-3,9-diol | ||
| SMILES | CC(=CCC1=C(C=CC2=C1OC3C2COC4=CC(=CC(=C34)OC)O)O)C | ||
| Standard InChIKey | YKTZRMXYANFKQR-YCRPNKLZSA-N | ||
| Standard InChI | InChI=1S/C21H22O5/c1-11(2)4-5-14-16(23)7-6-13-15-10-25-18-9-12(22)8-17(24-3)19(18)21(15)26-20(13)14/h4,6-9,15,21-23H,5,10H2,1-3H3/t15-,21+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 2. 1-Methoxyphaseollidin shows inhibition of lysoPAF acetyltransferase activity. 3. 1-Methoxyphaseollidin may show moderate cytotoxic activity against KB and L1210 cells. |
| Targets | PAFR | Antifection |
1-Methoxyphaseollidin Dilution Calculator
1-Methoxyphaseollidin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8217 mL | 14.1084 mL | 28.2167 mL | 56.4334 mL | 70.5418 mL |
| 5 mM | 0.5643 mL | 2.8217 mL | 5.6433 mL | 11.2867 mL | 14.1084 mL |
| 10 mM | 0.2822 mL | 1.4108 mL | 2.8217 mL | 5.6433 mL | 7.0542 mL |
| 50 mM | 0.0564 mL | 0.2822 mL | 0.5643 mL | 1.1287 mL | 1.4108 mL |
| 100 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.5643 mL | 0.7054 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- DL-Dab.2HCl
Catalog No.:BCC2669
CAS No.:65427-54-5
- Boc-Asn(Xan)-OH
Catalog No.:BCC3361
CAS No.:65420-40-8
- H-D-Asp-Ome
Catalog No.:BCC2896
CAS No.:65414-78-0
- Altholactone
Catalog No.:BCN4786
CAS No.:65408-91-5
- Morin hydrate
Catalog No.:BCC8214
CAS No.:654055-01-3
- Bestatin hydrochloride
Catalog No.:BCC3908
CAS No.:65391-42-6
- alpha-Isowighteone
Catalog No.:BCN4197
CAS No.:65388-03-6
- D-Chicoric Acid
Catalog No.:BCC8148
CAS No.:52248-48-3
- H-D-Pro-OMe.HCl
Catalog No.:BCC3025
CAS No.:65365-28-8
- 2,6-Tropanediol
Catalog No.:BCN1875
CAS No.:65356-02-7
- Demethylvestitol
Catalog No.:BCN4079
CAS No.:65332-45-8
- Scopolamine hydrobromide trihydrate
Catalog No.:BCC8188
CAS No.:6533-68-2
- Phebalosin
Catalog No.:BCN4198
CAS No.:6545-99-9
- Acantrifoic acid A
Catalog No.:BCN6488
CAS No.:654663-85-1
- Fmoc-Asn(Trt)-ol
Catalog No.:BCC2585
CAS No.:654670-89-0
- Sitagliptin phosphate monohydrate
Catalog No.:BCC2111
CAS No.:654671-77-9
- Sitagliptin phosphate
Catalog No.:BCC9148
CAS No.:654671-78-0
- (Z)-23-Coumaroylhederagenin
Catalog No.:BCN3748
CAS No.:654678-61-2
- Naftifine HCl
Catalog No.:BCC4806
CAS No.:65473-14-5
- Esculentoside A
Catalog No.:BCN5010
CAS No.:65497-07-6
- Cyclo(Pro-Ala)
Catalog No.:BCN2427
CAS No.:65556-33-4
- Europine N-oxide
Catalog No.:BCN1977
CAS No.:65582-53-8
- 1-Hydroxyacridone
Catalog No.:BCN7524
CAS No.:65582-54-9
- 4'-Demethylepipodophyllotoxin
Catalog No.:BCN5918
CAS No.:6559-91-7
Inhibition of lysoPAF acetyltransferase activity by components of licorice root.[Pubmed:10549875]
Biol Pharm Bull. 1999 Oct;22(10):1144-6.
Licorice root traditionally used as an anti-inflammatory drug exhibited an inhibitory effect on lysoPAF (platelet-activating factor) acetyltransferase in vitro: the ether soluble fraction of the crude drug produced a 27.3% inhibition at a concentration 10 microg/ml. From this fraction, licoricidin (1), 1-methoxyphaseollin (2), 6,8-diprenylgenistein (3) and 1-Methoxyphaseollidin (4) were isolated as active components, whose IC50 values were 7.7, 57, 19 and 48 microM, respectively. Licoricidin (1) seems to be one of the most potent compounds of plant origin isolated so far.
Anti-Helicobacter pylori flavonoids from licorice extract.[Pubmed:12127165]
Life Sci. 2002 Aug 9;71(12):1449-63.
Licorice is the most used crude drug in Kampo medicines (traditional Chinese medicines modified in Japan). The extract of the medicinal plant is also used as the basis of anti-ulcer medicines for treatment of peptic ulcer. Among the chemical constituents of the plant, glabridin and glabrene (components of Glycyrrhiza glabra), licochalcone A (G. inflata), licoricidin and licoisoflavone B (G. uralensis) exhibited inhibitory activity against the growth of Helicobacter pylori in vitro. These flavonoids also showed anti-H. pylori activity against a clarithromycin (CLAR) and amoxicillin (AMOX)-resistant strain. We also investigated the methanol extract of G. uralensis. From the extract, three new isoflavonoids (3-arylcoumarin, pterocarpan, and isoflavan) with a pyran ring, gancaonols A[bond]C, were isolated together with 15 known flavonoids. Among these compounds, vestitol, licoricone, 1-Methoxyphaseollidin and gancaonol C exhibited anti-H. pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. Glycyrin, formononetin, isolicoflavonol, glyasperin D, 6,8-diprenylorobol, gancaonin I, dihydrolicoisoflavone A, and gancaonol B possessed weaker anti-H. pylori activity. These compounds may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals.
