Products with Vasorelaxation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6434 | Notoginsenoside Ft1 |
| 1. Notoginsenoside Ft1 may accelerate diabetic wound healing by orchestrating multiple processes, including promoting fibroblast proliferation, enhancing angiogenesis, and attenuating inflammatory response, which provided a great potential application of it in clinics for patients with diabetic foot ulcers. 2. Notoginsenoside Ft1 can arrest the proliferation and elicited the apoptosis of SH-SY5Y cells possibly via p38 MAPK and ERK1/2 pathways, which indicates the potential therapeutic effect of it on human neuroblastoma. 3. Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries. 4. Notoginsenoside Ft1 can enhance platelet aggregation by activating a signalling network mediated through P2Y₁₂ receptors. 5. Notoginsenoside Ft1 is a novel stimulator of angiogenesis, it stimulates angiogenesis via HIF-1α-mediated VEGF expression, with PI3K/AKT and Raf/MEK/ERK signaling cascades concurrently participating in the process. | |
| BCN6506 | 1-Hydroxy-2,3,4,7-tetramethoxyxanthone |
| 1. 1-Hydroxy-2,3,4,7-tetramethoxy-xanthone can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 2. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells. | |
| BCN6548 | 4'-Hydroxyflavanone |
| 4'-Hydroxyflavanone may have major potential as a pharmaceutical preparation against hepatic steatosis and dyslipidemia. 4'-Hydroxyflavanone shows full vasorelaxing effects; it also shows inhibition of nitric oxide production in lipopolysaccharide (LPS)-stimulated product of nitrite in RAW 264.7 cells with the IC50 value of 15.72 ug/mL. | |
| BCN6563 | Eudesmin |
| Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways. | |
| BCN6569 | 1-Hydroxy-2,3,5-trimethoxyxanthone |
| 1. 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. 2. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells, it exhibits significant inhibition of osteoclast differentiation even at a low concentration (0.01 ug/mL) in a dose-dependent manner, and it can significantly reduce the pit formation on the dentine slice compared with the control group. 3. HM-1 can protect mice from the acute lung injury induced by ipopolysaccharide (LPS), which is relative to the increasing of IκB-α protein expression and the suppressing of inducible nitric oxide synthase and cyclooxygenase-Ⅱ protein expression. | |
