Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3198 | Corylifol A |
| Corylifol A is a naturally occurring potent inhibitor of hCE2 and UDP-glucuronosyltransferase 1A1 (UGT1A1); it could be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. Corylifol A has antiinflammatory activity, it shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uΜ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells. | |
| BCN3206 | Lucidal |
| 1. Lucialdehyde C (Lucidal) exhibits potent cytotoxicity against LLC, T-47D, Sarcoma 180, and Meth-A tumor cells with ED(50) values of 10.7, 4.7, 7.1, and 3.8 microg/ml, respectively. | |
| BCN3224 | Voacangine |
| 1. Voacangine is a novel transient receptor potential vanilloid type 1 (TRPV1) antagonist. 2. Voacangine shows mod. cytotoxic activity, also some CNS, brachycardial and hypotensive action. 3. Voacangine significantly suppresses in vitro angiogenesis, such as VEGF-induced tube formation and chemoinvasion. 4. Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50, 9 μM), but it shows noncompetitive inhibition against icilin (IC50, 7 μM), it may contribute to the development of a novel class of stimulus-selective TRPM8 blockers. | |
| BCN3229 | Daphnenone |
| 1. Daphnenone shows cytotoxic activity against the tumor cells of human melanoma A375-S2 , with the IC(50) value of 29.8 uM. | |
| BCN3236 | Rabdosin B |
| 1. Rabdosin B at higher concentrations inhibits root growth by affecting both cell length in the mature region and division of meristematic cells. 2. Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines. 3. Rabdosin B induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. | |
