Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3256 | Licoflavone C |
| 1. Licoflavone C has cytotoxic effect . 2. Licoflavone C has antioxidative effect. 3. Licoflavone C has protective effect toward the chromosome damage induced by DAU or MMC in cultured human peripheral lymphocytes. 4. Licoflavone C exhibits a dose-dependent antagonistic activity at concentrations up to 10−4 M, but stimulates β-galactosidase expression at higher concentrations resulting in a U-shaped-like dose-response curve. | |
| BCN3278 | Shikokianin |
| 1. Shikokianin shows inhibitory effects on DU145 cells with IC(50) values 4.24 microM, and LoVo cells with IC(50) values 17.55 microM. | |
| BCN3296 | Dicentrine |
| 1. Dicentrine has antinociception in different models of chemical pain. 2. Dicentrine induces DNA lesions to arrest cell cycle. 3. Dicentrine, a selective α(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities. 4. Callus and cell suspension cultures of S. venosa can produce high levels of Dicentrine as an alternative source of plant materials. | |
| BCN3326 | 5-Methoxycanthin-6-one |
| 1. 5-Methoxycanthin-6-one exhibits a clear suppressive effect on the phagocytosis response upon activation with serum-opsonized zymosan in the range of IC₅₀ = 0.9-2.0 uM versus ibuprofen with IC₅₀ = 12.1 uM. 2. 5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC₅₀ values ranging from 13.5-15.4 uM versus doxorubicine with IC₅₀ = 1.5 uM. | |
| BCN3330 | Trametenolic acid |
| 1. Trametenolic acid is a cytotoxic agent. 2. Trametenolic acid and Betulin as a new candidate of potent tyrosinase inhibitors, can decrease tyrosinase activity and melanin content. 3. Trametenolic acid exhibits a mode of mixed inhibition with a K I of 0.9 μM, K IS of 0.5 μM, and an IC50 of 7.25 μM. | |
