Products with Cancer chemoprevention bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6202 | Isocoronarin D |
| 1. Isocoronarin D shows the highest Hb F induction effect of 1.6-fold at 20 microM. 2. Isocoronarin D can activate antioxidant response element (ARE) (EC50 57.6 ± 2.4 uM), it may have potential chemopreventive activity. 3. Isocoronarin D is a main active ingredient for inducing death of the tested cancer cells, it possesses a wide anti-cancer capability. | |
| BCN6253 | 21-Episerratenediol |
| 1. 21-Episerratenediol may be as a potent cancer chemopreventive agent. | |
| BCN6309 | Coumarin |
| Coumarin is an anticoagulant and photoprotective drug; it also has antiulcerogenic activity, which may influence the secretion control mediated by the parasympathetic system. Coumarin is a potent inducer of aflatoxin B1-aldehyde reductase, has chemoprevention of aflatoxin B1 hepatocarcinogenesis. | |
| BCN6468 | Toxicarolisoflavone |
| Toxicarolisoflavone is an isoflavone extracted from Derris trifoliata Lour. | |
| BCN6790 | Dehydroglyasperin C |
| 1. Dehydroglyasperin C exhibits cancer chemopreventive potential via its inhibitory effect on TPA-induced neoplastic cell transformation and COX-2 modulation through regulation of the MKK4 and PI3K pathways. 2. Dehydroglyasperin C may inhibit microglia hyperactivation by increasing MKP-1 expression and acting as a potent anti-neurodegenerative agent. 3. Dehydroglyasperin C possesses potent antioxidant activity, suggests that it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive. 4. Dehydroglyasperin C can attenuate proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells. 5. Dehydroglyasperin C protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways. 6. Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. | |
