Products with Antileukaemic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4328 | Dehydrocrebanine |
| 1. Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. 2. Dehydrocrebanine shows potent antimalarial activity with an IC50 value of 70 ng/ml. | |
| BCN4390 | Eriocalyxin B |
| 1. Eriocalyxin B is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. 2. Eriocalyxin B reversibly interfer with the binding of p65 and p50 subunits to the DNA in a noncompetitive manner. 3. Eriocalyxin B exerts potent antiinflammatory effects through selective modulation of pathogenic Th1 and Th17 cells by targeting critical signaling pathways. 4. Eriocalyxin B inhibits proliferation and induces apoptosis through downregulation of Bcl-2 and activation of caspase-3 in human bladder cancer cells. 5. Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment. 6. Eriocalyxin B is a specific inhibitor of STAT3, it directly targets STAT3 through a covalent linkage to inhibit the phosphorylation and activation of STAT3 and induces apoptosis of STAT3-dependent tumor cells. | |
| BCN4582 | Isoscopoletin |
| Isoscopoletin possesses inhibitory activity against hepatitis B virus (HBV) replication; it also shows substantial inhibition against multi-drug resistant CEM/ADR5000 cells and human CCRF-CEM leukaemia cells, with the IC50 value is 1.6 and 4.0 microM, respectively. | |
| BCN4702 | 14-Deoxy-11-hydroxyandrographolide |
| 1. 14-Deoxy-11-hydroxyandrographolide shows potent cell differentiation-inducing activity towards mouse myeloid leukemia (M1) cells. | |
| BCN4717 | 28-Deoxonimbolide |
| 1. 28-Deoxonimbolide exhibits potent cytotoxic activity against HL60 leukemia cells. | |
