Products with Antibacterial Bioactivity

Explore BioCrick products associated with Antibacterial biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN5166	Communic acid
1. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression. 2. Communic acid has antibacterial activity, including against mycobacterial. 3. trans-Communic acid exhibits protective effects against UVB-induced skin aging by suppressing UVB-induced MMP-1 expression. 4. trans-Communic acid shows considerable cytotoxicity against four human cancer cell lines in vitro. 5. trans-Communic acid shows good activity against Mycobacterium aurum (MIC of 13.2 microM).
BCN5178	Reynosin
1. Reynosin has hepatoprotective effects, it can inhibit thioacetamide-induced apoptosis in primary hepatocytes and an in vivo mouse model. 2. Reynosin has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of α-synuclein protein expression. 3. Reynosin exhibits a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 microM. 4. Reynosin has strong anti-mycobactericidal activity, with a minimal bactericidal concentration (MBC) of 128ug/mL against the H37Rv, 366-2009 and 104-2010 Mtb strains and a minimal inhibitory concentration (MIC) of 64, 64, 128, 128 and 128ug/mL against the H37Rv, 104-2010, 63-2009, 366-2009 and 430-2010 Mtb strains, respectively. 5. Reynosin can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophages. 6. Reynosin shows cytotoxicity against the KB cancer cell line (ATCC CCL17), with IC50 value of 2.7 microg/mL. 7. Reynosin shows moderate anti-inflammatory activity, it exhibits a concentration-related decrease in the levels of IL-1β, IL-6, TNF-α, PGE2, lipoxgenase-5, and COX-2.
BCN5187	Heraclenin
1. Heraclenin and imperatorin have an equally strong clastogenic effect . 2. Heraclenin can induce apoptosis in Jurkat leukemia cells. 3. Heraclenin has mutagenicity in Chlamydomonas reinhardii. 4. (+)-Heraclenin displays significant levels of antiplasmodial and moderate levels of antimicrobial activities. 5. Heraclenin has anticoagulant activity. 6. Heraclenin shows anti-inflammatory activity.
BCN5194	5-Hydroxy-3',4',7-trimethoxyflavone
5-Hydroxy-3',4',7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml. 5-Hydroxy-3',4',7-trimethoxyflavone shows prominent inhibitory activity against soybean lipoxygenase, it can significantly inhibit nitric oxide production and induce reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-induced inflammation in RAW 264.7 macrophages.
BCN5204	Astilbin
Astilbin has insecticidal, antioxidant, antibacterial, and anti-inflammatory activities, it may act as an efficient therapeutic agent for arthritis like cyclosporine A but with less toxicity, its mechanism includes a selective suppression on lymphocyte functions via reducing MMP and NO production. Astilbin can exert an early renal protective role to diabetic nephropathy (DN), inhibit production of transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF).Astilbin also alleviates contact hypersensitivity through a unique mechanism involving a negative cytokine regulation through stimulating IL-10, which is distinct from the immunosuppressant cyclosporin A.

Antibacterial Bioactivity Products