Home >> Bioactivity >> Anti-trypanosoma

Products with Anti-trypanosoma bioactivity

Cat.No.	Product Name
BCN4135	Vitexilactone
1. Vitexilactone dramatically induces apoptosis both on tsFT210 and K562 cells at higher concentrations while at lower concentrations it inhibits the cell cycle progression of both tsFT210 and K562 cells at the G0/G1 phase; it is one anticancer component of Vitex trifolia L., which exerts its anti-proliferative effect on cancer cells through inducing apoptosis and inhibiting the cell cycle. 2. Vitexilactone has trypanocidal activity, the minimum lethal concentration against epimastigotes of Trypanosoma cruzi is 66 microM . 3. Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase.
BCN4308	3-Epikatonic acid
1. Epikatonic acid shows less active against T. (S.) cruzi trypanosome.
BCN4680	Kolavenol
1. Kolavenol shows a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
BCN4936	Horminone
1. Horminone may inhibit the initial steps of protein synthesis. 2. After administration of plant extracts containing Horminone has possibility of toxic effect. 3. Horminone and tingenone can inhibit the in vitro growth of Trypanosoma cruzi, 30 microM drug concentration producing total inhibition of growth. 4. Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria. 5. Horminone displays marked concentration-dependent antiproliferative effects.
BCN5053	Conocarpan
1. Conocarpan has antinociceptive effects. 2. Conocarpan is quite active against S. aureus and B. subtilis with MIC of 6.25 micrograms/ml, it also shows activity against M. tuberculosis (MIC=15.6 ug/ml). 3. Conocarpan shows considerable activity against epimastigote forms of T. cruzi, with 50% inhibition concentrations (IC50) of 8.0 microg/ml.