Products with Anti-proliferation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6669 | Methyl p-hydroxyphenyllactate |
| 1. Methyl para-hydroxyphenyllactate(MeHPLA) can suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo, high affinity of MeHPLA for the type II estrogen binding site (EBS) suggests that this interaction is responsible for the observed suppression of cell growth. | |
| BCN6685 | Zanthobungeanine |
| 1. Zanthobungeanine shows the inhibitory action on the development of A549 cell only in high concentration and has no antipersonnel effect on A549 cell. 2. Zanthobungeanine has anti-inflammatory activity, it shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L. 3. Zanthobungeanine shows obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF). | |
| BCN6696 | Delta-Tocotrienol |
| 1. Delta-tocotrienol displays significant radioprotective effects, it protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. 2. Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tube formation, migration, and adhesion on human umbilical vein endothelial cells. 3.Delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. 4.Grape seed polyphenol and delta-tocotrienol may have benefits in reducing non-alcoholic steatohepatitis (NASH, the second phase in liver disease). | |
| BCN6774 | Uncarinic acid E |
| 1. Uncarinic acid E shows moderate cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549) (IC50 < 20.0 uM). 2. Uncarinic acid E induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. 3. Uncarinic acid E shows dose-dependent inhibitory activities against PLCgamma1 in vitro with the IC(50) value of 9.5-44.6 microM and inhibits the proliferation of human cancer cells with the IC(50) value of 0.5-6.5 microg/mL. 4. A mixture of uncarinic acid E and 27-O-p-(E)-coumaroyloxyursolic acid exhibits antiplasmodial activity, with the IC50 value of 2.9 microg/ml. | |
| BCN6791 | Cytosporone B |
| Cytosporone B is a naturally occurring agonist for Nur77, it also is a Salmonella pathogenicity island 1 (SPI-1)-inhibitor, it may have potential in drug development against antibiotic-resistant Salmonella. Cytosporone B can elevate blood glucose levels in fasting C57 mice, an effect that is accompanied by induction of multiple genes involved in gluconeogenesis. Cytosporone B can inhibit transforming growth factor-b (TGF-β)-induced contraction of human corneal fibroblasts (HCFs), likely as a result of its attenuation of the up-regulation of α-SMA expression. | |
