Products with Anti-cerebral ischemia bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6211 | Gardenine |
| 1. Gardenin has regulatory effect on the gene expression in rats with focal cerebral ischemia. | |
| BCN6266 | Sodium Aescinate |
| 1. Sodium aescinate has anti-inflammatory and antioxidant activities, may effectively control and improve wound healing in diabetic rats. 2. Sodium aescinate can protect the lung injury induced by intestinal ischemia/reperfusion (I/R), which may be mediated by inhibiting lipid peroxidation, upregulating Bcl-2 gene protein expression, improving the ratio of Bcl-2/ Bax to inhibit lung apoptosis. 3. Sodium aescinate has obvious antiangiogenic effect, the initiation of angiogenesis and proliferation of endothelial cell are inhibited and the secretion of VEGF is also decreased. 4. Sodium aescinate has immunity enhancing and antioxidative effects, sodium aescinate injection liquid can decrease oxidative injury and enhance immunity functions in hepatocellular carcinoma (HCC) mice. 5. Sodium aescinate can protect against liver injury induced by methyl parathion and that the mechanism of action is related to its antioxidative and anti-inflammatory effects. | |
| BCN6311 | Icariin |
| Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Icariin has been reported to have anti-hypoxic, phytoestrogenic, anti-osteoporotic, anti-inflammatory, neuroprotective, and anti-depressant-like activities. Icariin is effective in the attenuation of AHR and chronic airway inflammatory changes in OVA-induced murine asthma model, and this effect is associated with regulation of Th17/Treg responses. Icariin inhibited NF-κB signaling activation and the NLRP3-inflammasome/caspase-1/IL-1β axis. | |
| BCN6323 | Picroside II |
| Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities. It has potent anti-apoptotic activity against renal I/R injury by suppressing the TLR4/NF-κB signaling pathway, it can protect the ischemic kidney against renal fibrosis and improve the neurological function of rats upon cerebral ischemia reperfusion injury. Picroside II enhances nerve growth factor (NGF)-induced neurite outgrowth from PC12D cells by amplifying a down-stream step of MAP kinase in the NGF receptor-mediated intracellular MAP kinase-dependent signaling pathway. | |
| BCN8184 | Pulsatilla camphor |
| 1. Pulsatilla saponin D exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activity of chemotherapeutic agents against HeLa cells. 2. Pulsatilla saponin D has strong haemolytic activity. | |
