Cystic Fibrosis Research
Cystic fibrosis (CF) is a common inherited disease that mostly affects the lungs and airways of a sufferer. One of the main pathological characteristics of CF is the failure of airway defence against bacterial infection, leading to frequent chest infection and progressive lung damage.
Cystic Fibrosis Research Products Targets
Products for Cystic Fibrosis Research - Page 13
- Cat.No. Product Name Information/Activity
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BCC4003
ZIP
Cell-permeable inhibitor of atypical PKC isozyme PKM<span class='symbol'>ζ</span>
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BCC7343
Bryostatin 1
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties.
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BCC5619
Bryostatin 2
87745-28-6
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BCC5620
Bryostatin 3
143370-84-7
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BCC7564
FR 236924
DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε.
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BCC7870
Phorbol 12,13-dibutyrate
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter.
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BCN2511
12-O-tetradecanoylphorbol-13-acetate
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator.
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BCC6643
SC-10
102649-79-6
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BCC6646
SC-9
102649-78-5
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BCC2390
Oncrasin 1
Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.
