Glutamate (Metabotropic) Group I Receptor
Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are divided into two subtypes, mGlu1 and mGlu5.
Products for Glutamate (Metabotropic) Group I Receptor - Page 3
- Cat.No. Product Name Information/Activity
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BCC7345
Fenobam
Fenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity.
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BCC7166
HexylHIBO
334887-43-3
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BCC7167
(S)-HexylHIBO
334887-48-8
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BCC7332
JNJ 16259685
JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
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BCC6983
LY 367385
LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects.
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BCC7347
LY 456236 hydrochloride
338736-46-2
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BCC7281
3-MATIDA
518357-51-2
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BCC7756
(RS)-MCPG disodium salt
1303994-09-3
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BCC6610
(RS)-MCPG
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.
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BCC6611
(S)-MCPG
(S)-MCPG is the active isomer of (RS)-MCPG (Cat.
