Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory disease of the central nervous system (CNS), which causes damage to myelin and axons, resulting in neurological symptoms such as partial loss of sight, paresthesias and ataxia.

Multiple Sclerosis Products Targets

Products for Multiple Sclerosis - Page 16

Cat.No. Product Name Information/Activity
BCC6355 TC-E 5001 865565-29-3
BCC2455 WIKI4 WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM.
BCC1120 XAV-939 XAV-939 is a potent tankyrase inhibitor that targets Wnt/β-catenin signaling. XAV-939 stabilizes axin by inhibiting tankyrase 1 and tankyrase 2 (IC50s of 5 and 2 nM, respectively), thereby stimulating β-catenin degradation. XAV939 binds tightly to the catalytic (PARP) domains of TNKS1 and TNKS2 (Kds of 99 and 93 nM, respectively).
BCC4074 Icilin Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.
BCC7543 WS 12 WS-12 is an agonist of TRPM8 with an EC50 of 39 nM.
BCC6419 RQ-00203078 RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1.
BCC7834 AMTB hydrochloride 926023-82-7
BCC6367 Ononetin 487-49-0
BCC7989 9-Phenanthrol 484-17-3
BCC6244 TC-I 2000 1159996-20-9