Mitochondrial Permeability Transition Pore
The mitochondrial permeability transition pore (MPTP) is a Ca2+-dependent, nonselective pore located on the inner mitochondrial membrane. It opens in response to elevated matrix Ca2+ concentrations, increasing mitochondrial membrane permeability.
Products for Mitochondrial Permeability Transition Pore
- Cat.No. Product Name Information/Activity
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BCC4773
Cyclosporin A
Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.
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BCC5288
TRO 19622
Olesoxime (TRO 19622) is a mitochondrial-targeted neuroprotective compound with mean EC50 value for increasing cell survival is 3.2±0.2 µM.
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BCC7952
Auranofin
Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.2 μM.
