Intracellular Signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.

Intracellular Signaling Products Targets

Products for Intracellular Signaling - Page 61

  1. Cat.No. Product Name Information/Activity
  2. BCC2278 Pioglitazone HCl Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone HCl chemical structure
  3. BCC7321 15-deoxy-Δ-12,14-Prostaglandin J2 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM. 15-deoxy-Δ-12,14-Prostaglandin J2 chemical structure
  4. BCC2264 Rosiglitazone Rosiglitazone (BRL 49653) is a selective PPARγ activator with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone chemical structure
  5. BCC7751 S26948 353280-43-0 S26948 chemical structure
  6. BCC3863 Telmisattan Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM. Telmisattan chemical structure
  7. BCC2016 Troglitazone Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively. Troglitazone chemical structure
  8. BCC7022 BADGE 1675-54-3 BADGE chemical structure
  9. BCC2260 GW9662 GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively. GW9662 chemical structure
  10. BCC7243 SR 202 Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects. SR 202 chemical structure
  11. BCC2261 T0070907 T0070907 is a potent PPARγ antagonist with a Ki of 1 nM. T0070907 chemical structure

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