Intracellular Signaling
Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.
Intracellular Signaling Products Targets
- Cdc25 Phosphatase (2)
- STAT (10)
- PI 3-kinase (22)
- JAK (10)
- PFKFB3 (3)
- Hexokinases (1)
- Protein Kinase G (3)
- NFKB and IKB (30)
- Others (3)
- Cyclooxygenase (24)
- IRAK (1)
- PORCN (4)
- beta-catenin (13)
- PPARγ (16)
- PPARδ (5)
- PPARα (7)
- Inositol Phosphatase (3)
- MYC (1)
- Sphingosine Kinase (2)
- RSK (4)
- Protein Kinase D (3)
- Polo-like Kinase (5)
- Pim Kinase (4)
- PERK (2)
- Phosphoinositide-dependent Kinase 1 (5)
- P21-activated Kinases (2)
- Myosin Light Chain Kinase (4)
- mTOR (14)
- Monopolar Spindle 1 Kinase (2)
- Mnk (2)
- MK2 (2)
- MEK (9)
- LIMK (3)
- Focal Adhesion Kinase (4)
- DNA-Dependent Protein Kinase (6)
- Diacylglycerol Kinase (2)
- Death-Associated Protein Kinase (1)
- Checkpoint Kinase (3)
- Casein Kinase 2 (3)
- Casein Kinase 1 (7)
- Bruton's Tyrosine Kinase (3)
- ATM and ATR Kinase (3)
- Akt (Protein Kinase B) (11)
- Adeonsine Kinase (2)
- Abl Kinase (9)
- Hsp90 (10)
- Hsp70 (4)
- Protein Kinase A (9)
- Protein Kinase C (29)
- Calmodulin-Dependent Kinase (8)
- LRRK2 (4)
- ERK (6)
- DYRK (3)
- Estrogen and Related Receptor (33)
- Tankyrase (5)
- ITK (2)
- ASK1 (2)
- Syk Kinase (4)
- Src Kinase (21)
- Raf Kinase (7)
- IαB Kinase (6)
- p38 MAPK (16)
- Janus N-terminal Kinase (12)
- Androgen Receptor (11)
- Glycogen Synthase Kinase 3 (20)
- AMPK (7)
- Rho-Kinases (9)
- AP-1 (2)
- SREBP (2)
- NUAK (2)
- Telomerase (3)
- Retinoid X Receptor (13)
- Retinoic Acid Receptor (22)
- Proteasome (5)
- Phospholipase (16)
- Lipase (4)
- G Protein (Small) (23)
- Hedgehog Signaling (15)
- DNA Topoisomerase (12)
- DNA, RNA and Protein Synthesis (46)
- Protein Tyrosine Phosphatases (5)
- Protein serine and threonine phosphatase (16)
- Histone Deacetylase (19)
- Aurora Kinase (9)
- Cyclin-Dependent Protein Kinase (21)
Products for Intracellular Signaling - Page 61
- Cat.No. Product Name Information/Activity
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BCC2278
Pioglitazone HCl
Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
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BCC7321
15-deoxy-Δ-12,14-Prostaglandin J2
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.
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BCC2264
Rosiglitazone
Rosiglitazone (BRL 49653) is a selective PPARγ activator with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.
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BCC7751
S26948
353280-43-0
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BCC3863
Telmisattan
Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
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BCC2016
Troglitazone
Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively.
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BCC7022
BADGE
1675-54-3
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BCC2260
GW9662
GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.
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BCC7243
SR 202
Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects.
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BCC2261
T0070907
T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.


