Cancer Research

Cancer is a term used to define a group of diseases in which abnormal cells divide without control, are able to invade neighboring tissues/organs and metastasize. Cancer has been characterized by six hallmarks; self sufficiency in proliferative growth signals, insensitivity to growth inhibitors, evasion of apoptosis, limitless replicative potential, ability to develop blood vessels (angiogenesis), and tissue invasion and metastasis.

Cancer Research Products Areas

Products for Cancer Research - Page 55

Cat.No. Product Name Information/Activity
BCC2459 DL-AP3 Phosphoserine phosphatase inhibitor
BCC2456 Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor
BCC2457 Calyculin A Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM.
BCN1280 Cantharidin Cantharidin, a natural toxin isolated from beetles in the families Meloidae and Oedemeridae, has been reported to be toxic to some pests, including the diamondback moth.
BCC4773 Cyclosporin A Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.
BCC4952 Tacrolimus (FK506) Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
BCC2460 Fostriecin sodium salt Potent PP2A and PP4 inhibitor
BCC2461 Fumonisin B1 Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin.
BCC4179 GSK 2830371 GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM.
BCC2462 INCA-6 Inhibitor of calcineurin-substrate association