YE 120GPR35 agonist CAS# 383124-82-1 |
Related Products
- Hydroxyfasudil
Catalog No.:BCC1635
CAS No.:105628-72-6
- chroman 1
Catalog No.:BCC1480
CAS No.:1273579-40-0
- Y-27632 dihydrochloride
Catalog No.:BCC1273
CAS No.:129830-38-2
- H-1152
Catalog No.:BCC1615
CAS No.:451462-58-1
- H-1152 dihydrochloride
Catalog No.:BCC1616
CAS No.:871543-07-6
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 383124-82-1 | SDF | Download SDF |
| PubChem ID | 12138435 | Appearance | Powder |
| Formula | C16H9Cl2N3O | M.Wt | 330.17 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| Chemical Name | 2-[3-cyano-5-(3,4-dichlorophenyl)-4,5-dimethylfuran-2-ylidene]propanedinitrile | ||
| SMILES | CC1=C(C(=C(C#N)C#N)OC1(C)C2=CC(=C(C=C2)Cl)Cl)C#N | ||
| Standard InChIKey | RSWZFAPYKOARNG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H9Cl2N3O/c1-9-12(8-21)15(10(6-19)7-20)22-16(9,2)11-3-4-13(17)14(18)5-11/h3-5H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | GPR35 agonist (EC50 = 32 nM in DMR assays). Also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM). |
YE 120 Dilution Calculator
YE 120 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0287 mL | 15.1437 mL | 30.2874 mL | 60.5749 mL | 75.7186 mL |
| 5 mM | 0.6057 mL | 3.0287 mL | 6.0575 mL | 12.115 mL | 15.1437 mL |
| 10 mM | 0.3029 mL | 1.5144 mL | 3.0287 mL | 6.0575 mL | 7.5719 mL |
| 50 mM | 0.0606 mL | 0.3029 mL | 0.6057 mL | 1.2115 mL | 1.5144 mL |
| 100 mM | 0.0303 mL | 0.1514 mL | 0.3029 mL | 0.6057 mL | 0.7572 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- Minoxidil
Catalog No.:BCC4297
CAS No.:38304-91-5
- Naringenin trimethyl ether
Catalog No.:BCN5437
CAS No.:38302-15-7
- Burchellin
Catalog No.:BCN6676
CAS No.:38276-59-4
- Glucose-conjugated MGMT inhibitor
Catalog No.:BCC1597
CAS No.:382607-78-5
- Malonomicin
Catalog No.:BCN1844
CAS No.:38249-71-7
- 20(R)-Ginsenoside Rg3
Catalog No.:BCN5018
CAS No.:38243-03-7
- beta-Amyrenonol
Catalog No.:BCN5436
CAS No.:38242-02-3
- Enhydrin chlorohydrin
Catalog No.:BCN4639
CAS No.:38230-99-8
- Anhydroicaritin
Catalog No.:BCN5351
CAS No.:38226-86-7
- Filixic acid ABA
Catalog No.:BCN6330
CAS No.:38226-84-5
- Pyroxamide
Catalog No.:BCC2424
CAS No.:382180-17-8
- Coumarin VI
Catalog No.:BCN7833
CAS No.:38215-36-0
New Products
- 3-O-beta-D-Glucopyranosylplatycodigenin
Catalog No.:BCN7832
CAS No.:38337-25-6
- Homovanillic Acid Sulfate
Catalog No.:BCN2226
CAS No.:38339-06-9
- UC 112
Catalog No.:BCC8042
CAS No.:383392-66-3
- Neuropeptide W-23 (human)
Catalog No.:BCC5961
CAS No.:383415-79-0
- Taxinine
Catalog No.:BCN6944
CAS No.:3835-52-7
- 3',4'-Anhydrovinblastine
Catalog No.:BCN2392
CAS No.:38390-45-3
- NSC 663284
Catalog No.:BCC7199
CAS No.:383907-43-5
- Caudatin
Catalog No.:BCN5810
CAS No.:38395-02-7
- Ganaxolone
Catalog No.:BCC7397
CAS No.:38398-32-2
- Aloenin
Catalog No.:BCN8438
CAS No.:38412-46-3
- Altechromone A
Catalog No.:BCN7422
CAS No.:38412-47-4
- 3,4,4',7-Tetrahydroxyflavan
Catalog No.:BCN5438
CAS No.:38412-82-7
Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists.[Pubmed:21950657]
J Med Chem. 2011 Oct 27;54(20):7385-96.
Screening with dynamic mass redistribution (DMR) assays in a native cell line HT-29 led to identification of two novel series of chemical compounds, 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives, as GPR35 agonists. Of these, 2-(3-cyano-5-(3,4-dichlorophenyl)-4,5-dimethylfuran-2(5H)-ylidene)malononitrile (YE120) and 6-bromo-3-methylthieno[3,2-b]thiophene-2-carboxylic acid (YE210) were found to be the two most potent GPR35 agonists with an EC(50) of 32.5 +/- 1.7 nM and 63.7 +/- 4.1 nM, respectively. Both agonists exhibited better potency than that of zaprinast, a known GPR35 agonist. DMR antagonist assays, knockdown of GPR35 with interference RNA, receptor internalization assays, and Tango beta-arrestin translocation assays confirmed that the agonist activity of these ligands is specific to GPR35. The present study provides novel chemical series as a starting point for further investigations of GPR35 biology and pharmacology.
YE 120,383124-82-1,Natural Products,GPR35, buy YE 120 , YE 120 supplier , purchase YE 120 , YE 120 cost , YE 120 manufacturer , order YE 120 , high purity YE 120
