Xylazine HClα2 Adrenoceptor agonist CAS# 23076-35-9 |
Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 23076-35-9 | SDF | Download SDF |
| PubChem ID | 68554 | Appearance | Powder |
| Formula | C12H17ClN2S | M.Wt | 256.79 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | BAY 1470 hydrochloride | ||
| Solubility | DMSO : ≥ 100 mg/mL (389.42 mM) H2O : ≥ 50 mg/mL (194.71 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine;hydrochloride | ||
| SMILES | CC1=C(C(=CC=C1)C)NC2=NCCCS2.Cl | ||
| Standard InChIKey | QYEFBJRXKKSABU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.
Target: Adrenergic Receptor
Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence). We concluded that xylazine given by epidural injection results in safe, effective perineal analgesia in horses [2]. References: | |||||
Xylazine HCl Dilution Calculator
Xylazine HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.8942 mL | 19.4712 mL | 38.9423 mL | 77.8847 mL | 97.3558 mL |
| 5 mM | 0.7788 mL | 3.8942 mL | 7.7885 mL | 15.5769 mL | 19.4712 mL |
| 10 mM | 0.3894 mL | 1.9471 mL | 3.8942 mL | 7.7885 mL | 9.7356 mL |
| 50 mM | 0.0779 mL | 0.3894 mL | 0.7788 mL | 1.5577 mL | 1.9471 mL |
| 100 mM | 0.0389 mL | 0.1947 mL | 0.3894 mL | 0.7788 mL | 0.9736 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Xylazine HCl is a strong agonist of α2-adrenoceptor [1].
Xylazine HCl has been reported to stimulate the proliferation of rat thymocytes in vivo (at doses of 2.5 mg/kg and 5 mg/kg) and in vitro (at concentration of 5 mM) [2]. In the analgesic testing, Xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. In addition, Xylazine has also shown the inhibitory effect in the mouse vas deferens bioassay with the IC50 value of 18nM. Furthermore, Xylazine has displayed a potent specific [3H]-dihydromorphine binding inhibition with the IC50 value of 8μM in opiate receptor binding test [1].
References:
[1] S. BROWNING, D.LAWRENCE1, A.LIVINGSTON & B.MORRIS. Interaction of drugs active at opiate receptors and drugs active at α2-adrenoceptors on various test systems
[2] Colić M1, Cupić V, Pavicić L, Vucević D, Varagić VM. Xylazine, an alpha 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. Methods Find Exp Clin Pharmacol. 2000 Sep;22(7):557-62.
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Xylazine hydrochloride (BAY 1470 hydrochloride) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine.
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