W-5 hydrochlorideCAS# 61714-25-8 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 61714-25-8 | SDF | Download SDF |
| PubChem ID | 173829 | Appearance | Powder |
| Formula | C16H23ClN2O2S | M.Wt | 342.88 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 50 mM in DMSO and to 10 mM in water | ||
| Chemical Name | N-(6-aminohexyl)naphthalene-1-sulfonamide;hydrochloride | ||
| SMILES | C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)NCCCCCCN.Cl | ||
| Standard InChIKey | HOCSVIGHWPLMFC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Calmodulin antagonist (inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM). |
W-5 hydrochloride Dilution Calculator
W-5 hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9165 mL | 14.5824 mL | 29.1647 mL | 58.3294 mL | 72.9118 mL |
| 5 mM | 0.5833 mL | 2.9165 mL | 5.8329 mL | 11.6659 mL | 14.5824 mL |
| 10 mM | 0.2916 mL | 1.4582 mL | 2.9165 mL | 5.8329 mL | 7.2912 mL |
| 50 mM | 0.0583 mL | 0.2916 mL | 0.5833 mL | 1.1666 mL | 1.4582 mL |
| 100 mM | 0.0292 mL | 0.1458 mL | 0.2916 mL | 0.5833 mL | 0.7291 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.[Pubmed:6945588]
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4354-7.
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities. Autoradiographic studies using tritiated W-7 showed that this compound penetrates the cell membrane, is distributed mainly in the cytoplasm, and inhibits proliferation of Chinese hamster ovary K1 (CHO-K1) cells. Cytoplasmic [3H]W-7 was excluded completely within 6 hr after removal of [3H]W-7 from the culture medium. N-(6-aminohexyl)-1-naphthalenesulfonamide, an analogue of W-7 that interacts only weakly with calmodulin, proved to be a much weaker inhibitor of cell proliferation. CHO-K1 cells were synchronized by shaking during mitosis and then released into the cell cycle in the presence of 25 microM W-7 or 2.5 mM thymidine for 12 hr. Cell division was observed approximately 6 hr later. The results suggest that the effect of W-7 on cell proliferation might be through selective inhibition of the G1/S boundary phase, which is similar to the effect of excess thymidine. This pharmacological demonstration that cytoplasmic calmodulin is involved in cell proliferation is significant; W-7 and its derivatives may be useful tools for research on calmodulin and cell biology-related studies.
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