Vitamin B12CAS# 68-19-9 |
- Daptomycin
Catalog No.:BCC1057
CAS No.:103060-53-3
- Nelarabine
Catalog No.:BCC1072
CAS No.:121032-29-9
- Gemcitabine HCl
Catalog No.:BCC1076
CAS No.:122111-03-9
- Clofarabine
Catalog No.:BCC1078
CAS No.:123318-82-1
- Ifosfamide
Catalog No.:BCC1164
CAS No.:3778-73-2
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 68-19-9 | SDF | Download SDF |
| PubChem ID | 5311498 | Appearance | Powder |
| Formula | C63H88CoN14O14P | M.Wt | 1355.37 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Cyanocobalamin | ||
| Solubility | DMSO : 25 mg/mL (18.45 mM; Need ultrasonic) H2O : 12 mg/mL (8.85 mM; Need ultrasonic) | ||
| Chemical Name | cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,5Z,7S,10Z,12S,13S,15Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-24-id-3-yl]propanoylamino]propan-2-yl] phosphate;cyanide | ||
| SMILES | CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3] | ||
| Standard InChIKey | FDJOLVPMNUYSCM-WZHZPDAFSA-L | ||
| Standard InChI | InChI=1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.
Target: Others
Vitamin B12 is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis (especially odd chain fatty acids) and energy production.
Vitamin B12 normally plays a significant role in the metabolism of every cell of the body, especially affecting the DNA synthesis and regulation but also fatty acid synthesis and energy production. However, many (though not all) of the effects of functions of B12 can be replaced by sufficient quantities of folic acid (vitamin B9), since B12 is used to regenerate folate in the body. Most vitamin B12 deficiency symptoms are actually folate deficiency symptoms, since they include all the effects of pernicious anemia and megaloblastosis, which are due to poor synthesis of DNA when the body does not have a proper supply of folic acid for the production of thymine due to methyl trapping. When sufficient folic acid is available, all known B12 related deficiency syndromes normalize, save those narrowly connected with the vitamin B12-dependent enzymes Methylmalonyl Coenzyme A mutase, and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase; and the buildup of their respective substrates (methylmalonic acid, MMA) and homocysteine.Coenzyme B12's reactive C-Co bond participates in three main types of enzyme-catalyzed reactions [1, 2]. References: | |||||
Vitamin B12 Dilution Calculator
Vitamin B12 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.7378 mL | 3.689 mL | 7.3781 mL | 14.7561 mL | 18.4451 mL |
| 5 mM | 0.1476 mL | 0.7378 mL | 1.4756 mL | 2.9512 mL | 3.689 mL |
| 10 mM | 0.0738 mL | 0.3689 mL | 0.7378 mL | 1.4756 mL | 1.8445 mL |
| 50 mM | 0.0148 mL | 0.0738 mL | 0.1476 mL | 0.2951 mL | 0.3689 mL |
| 100 mM | 0.0074 mL | 0.0369 mL | 0.0738 mL | 0.1476 mL | 0.1845 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Vitamin B12
- Sodium citrate
Catalog No.:BCC7588
CAS No.:68-04-2
- BMS 193885
Catalog No.:BCC7613
CAS No.:679839-66-8
- N-(15-Methyl-9-hexadecenoyl)taurine
Catalog No.:BCN1754
CAS No.:679834-30-1
- N-(5,8,11,14-Eicosatetraenoyl)taurine
Catalog No.:BCN1755
CAS No.:679834-28-7
- Aurantio-obtusin
Catalog No.:BCN1222
CAS No.:67979-25-3
- Sodium Danshensu
Catalog No.:BCN5952
CAS No.:67920-52-9
- 1,6-Dihydro-4,7'-epoxy-1-methoxy-3',4'-methylenedioxy-6-oxo-3,8'-lignan
Catalog No.:BCN6584
CAS No.:67920-48-3
- Mesaconine
Catalog No.:BCC8339
CAS No.:6792-09-2
- Macusine B
Catalog No.:BCN6471
CAS No.:6792-07-0
- Homobaldrinal
Catalog No.:BCN2681
CAS No.:67910-07-0
- Dehydroevodiamine
Catalog No.:BCN2974
CAS No.:67909-49-3
- Aluminum n-octacosoxide
Catalog No.:BCC8099
CAS No.:67905-27-5
- Norethindrone
Catalog No.:BCC4811
CAS No.:68-22-4
- Vitamin A
Catalog No.:BCN8349
CAS No.:68-26-8
- Sulfadiazine
Catalog No.:BCC3859
CAS No.:68-35-9
- Hydroxyzine
Catalog No.:BCC5209
CAS No.:68-88-2
- Metamizole sodium
Catalog No.:BCC9024
CAS No.:68-89-3
- Hypoxanthine
Catalog No.:BCC5324
CAS No.:68-94-0
- Ac-Pro-OH
Catalog No.:BCC3017
CAS No.:68-95-1
- Hydroxyprogesterone
Catalog No.:BCC8996
CAS No.:68-96-2
- Magnocurarine
Catalog No.:BCN3839
CAS No.:6801-40-7
- Pulsatilla saponin H
Catalog No.:BCN8181
CAS No.:68027-14-5
- Pulsatilla saponin D
Catalog No.:BCN8526
CAS No.:68027-15-6
- Carbadox
Catalog No.:BCC3744
CAS No.:6804-07-5
Periconceptional folic acid supplementation and vitamin B12 status in a cohort of Chinese early pregnancy women with the risk of adverse pregnancy outcomes.[Pubmed:28366994]
J Clin Biochem Nutr. 2017 Mar;60(2):136-142.
Maternal folate and Vitamin B12 deficiency predict poor pregnancy outcome. To improve pregnancy outcomes in rural area of China, we investigate rural women's folic acid supplementation (FAS) status and the associations between maternal vitamin B status during the first trimester and subsequent adverse pregnancy outcomes. We collected the questionnaire information and drew 5 ml of blood from 309 early pregnant rural women. The birth outcomes were retrieved from medical records after delivery. Out of the total, 257 had taken FAS, including 50 before conception (group A) and 207 during the first trimester (group B). The concentration of plasma folate and the RBC folate supplementation groups were obviously higher than that of no-supplementation group (group N, p<0.01). The mean Vitamin B12 levels in FAS group were significantly higher than those in groups N and B (p<0.05). Women who delivered SGA or premature infants had reduced plasma folate levels (p<0.05) compared with controls. The multiple linear regression models revealed that RBC folate levels affected the infant birth weight (p<0.01) and birth length (p<0.05). In conclusion, FAS can significantly improve plasma folate and RBC folate levels in childbearing-age women and reduce the risk of subsequent adverse pregnancy outcomes.
Vitamin B12 deficiency from the perspective of a practicing hematologist.[Pubmed:28360040]
Blood. 2017 May 11;129(19):2603-2611.
B12 deficiency is the leading cause of megaloblastic anemia, and although more common in the elderly, can occur at any age. Clinical disease caused by B12 deficiency usually connotes severe deficiency, resulting from a failure of the gastric or ileal phase of physiological B12 absorption, best exemplified by the autoimmune disease pernicious anemia. There are many other causes of B12 deficiency, which range from severe to mild. Mild deficiency usually results from failure to render food B12 bioavailable or from dietary inadequacy. Although rarely resulting in megaloblastic anemia, mild deficiency may be associated with neurocognitive and other consequences. B12 deficiency is best diagnosed using a combination of tests because none alone is completely reliable. The features of B12 deficiency are variable and may be atypical. Timely diagnosis is important, and treatment is gratifying. Failure to diagnose B12 deficiency can have dire consequences, usually neurological. This review is written from the perspective of a practicing hematologist.
Possible effects of neonatal vitamin B12 status on TSH-screening program: a cross-sectional study from Turkey.[Pubmed:28350538]
J Pediatr Endocrinol Metab. 2017 May 1;30(5):551-555.
BACKGROUND: In this study we evaluated whether Vitamin B12 deficiency affects neonatal screening (NS) for congenital hypothyroidism (CH). METHODS: A cross-sectional study conducted from 2010 to 2011. A total of 10,740 infants were born in our hospital in this period. Thyroid-stimulating hormone (TSH) was tested for NS and neonates with abnormal screening results (TSH>20 mIU/L) were re-examined. Two hundred and twenty-nine re-called subjects (re-call rate 2.3%) were compared to 77 randomly selected newborns with normal TSH screening among these term newborns in terms of serum TSH, free T4, Vitamin B12 and homocysteine status. RESULTS: Of the 229 re-called subjects, 11 infants with CH and 21 infants with transient TSH elevation were detected. In the normal TSH screening group, only two infants were diagnosed with transient TSH elevation. Mean serum B12 levels were 126.4+/-48.7 pg/mL and 211.9+/-127.9 pg/mL in the positive TSH-screening group and the control group, respectively. There was a significant difference between positive and normal TSH-screening groups in regard to serum TSH, free T4, serum B12 and homocysteine levels. CONCLUSIONS: We found a significant Vitamin B12 deficiency in positive TSH-screening infants. Beside the crucial role of Vitamin B12 in newborns, deficiency seems to increase the recall rates of infants in an NS program for CH.
Maternofetal transport of vitamin B12: role of TCblR/CD320 and megalin.[Pubmed:28351841]
FASEB J. 2017 Jul;31(7):3098-3106.
Vitamin B12 deficiency causes megaloblastic anemia and neurologic disorder in humans. Gene defects of transcobalamin (TC) and the transcobalamin receptor (TCblR), needed for cellular uptake of the TC-bound B12, do not confer embryonic lethality. TC deficiency can produce the hematologic and neurologic complications after birth, whereas TCblR/CD320 gene defects appear to produce mild metabolic changes. Alternate maternofetal transport mechanisms appear to provide adequate B12 to the fetus. To understand this mechanism, we evaluated the role of TC, TCblR/CD320, and megalin in maternofetal transport of B12 in a TCblR/CD320-knockout (KO) mouse. Our results showed high expression of TCblR/CD320 in the labyrinth of the placenta, embryonic brain, and spinal column in wild-type (WT) mice. Megalin expression was about the same in both WT and KO mouse visceral yolk sac, brain, and spinal column. Megalin mRNA was down-regulated in the KO embryonic spinal cord (SC) and kidneys. Megalin expression remained unaltered in adult WT and KO mouse brain, SC, and kidneys. Injected dsRed-TC-B12 and TC-(57)CoB12 accumulated in the visceral yolk sac of KO mice where megalin is expressed and provides an alternate mechanism for the maternofetal transport of Cbl during fetal development.-Arora, K., Sequeira, J. M., Quadros, E. V. Maternofetal transport of Vitamin B12: role of TCblR/CD320 and megalin.
