Uncarine A

CAS# 6899-73-6

Uncarine A

Catalog No. BCN7767----Order now to get a substantial discount!

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Chemical structure

Uncarine A

3D structure

Chemical Properties of Uncarine A

Cas No. 6899-73-6 SDF Download SDF
PubChem ID 188999 Appearance Powder
Formula C21H24N2O4 M.Wt 368.42
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl (1R,4aS,5aS,6S,10aR)-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate
SMILES CC1C2CN3CCC4(C3CC2C(=CO1)C(=O)OC)C5=CC=CC=C5NC4=O
Standard InChIKey JMIAZDVHNCCPDM-DQDWJNSRSA-N
Standard InChI InChI=1S/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)/t12-,13+,14-,18+,21+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Uncarine A

The leaves of Uncaria hirsuta.

Biological Activity of Uncarine A

DescriptionUncarine A is a natural product from Uncaria hirsuta.

Protocol of Uncarine A

Structure Identification
Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(17):2124-8.

Studies on alkalodial constituents in leaves of Uncaria hirsuta.[Pubmed: 19066056]

To study the alkaloidial constituents of the leaves of uncaria hirsuta.
METHODS AND RESULTS:
Some chromatographic methods were applied to isolate pure compounds and their structures were elucidated by spectroscopic methods. Eleven compounds were isolated and identified as 19-epi-3-iso-ajmalicine (1), 3-isoajmalicine (2), harman (3), mitraphylline (4), isomitraphylline (5), isorhynchophylline (6), corynoxine (7), rhynchophylline (8), isomitraphyllic acid (9), Uncarine A (10) and uncarine B (11).
CONCLUSIONS:
Compounds 1-9 were firstly isolated from this plant.

Uncarine A Dilution Calculator

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Uncarine A Molarity Calculator

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Preparing Stock Solutions of Uncarine A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7143 mL 13.5715 mL 27.1429 mL 54.2859 mL 67.8573 mL
5 mM 0.5429 mL 2.7143 mL 5.4286 mL 10.8572 mL 13.5715 mL
10 mM 0.2714 mL 1.3571 mL 2.7143 mL 5.4286 mL 6.7857 mL
50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0857 mL 1.3571 mL
100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Uncarine A

[Studies on alkalodial constituents in leaves of Uncaria hirsuta].[Pubmed:19066056]

Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(17):2124-8.

OBJECTIVE: To study the alkaloidial constituents of the leaves of uncaria hirsuta. METHOD: Some chromatographic methods were applied to isolate pure compounds and their structures were elucidated by spectroscopic methods. RESULT: Eleven compounds were isolated and identified as 19-epi-3-iso-ajmalicine (1), 3-isoajmalicine (2), harman (3), mitraphylline (4), isomitraphylline (5), isorhynchophylline (6), corynoxine (7), rhynchophylline (8), isomitraphyllic acid (9), Uncarine A (10) and uncarine B (11). CONCLUSION: Compounds 1-9 were firstly isolated from this plant.

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