Tutin

CAS# 2571-22-4

Tutin

Catalog No. BCN5129----Order now to get a substantial discount!

Product Name & Size Price Stock
Tutin:5mg Please Inquire In Stock
Tutin:10mg Please Inquire In Stock
Tutin:20mg Please Inquire In Stock
Tutin:50mg Please Inquire In Stock

Quality Control of Tutin

Number of papers citing our products

Chemical structure

Tutin

3D structure

Chemical Properties of Tutin

Cas No. 2571-22-4 SDF Download SDF
PubChem ID 75729 Appearance Powder
Formula C15H18O6 M.Wt 294.3
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(=C)C1C2C(C3(C4(CO4)C5C(C3(C1C(=O)O2)O)O5)C)O
Standard InChIKey CCAZWUJBLXKBAY-ULZPOIKGSA-N
Standard InChI InChI=1S/C15H18O6/c1-5(2)6-7-12(17)20-8(6)9(16)13(3)14(4-19-14)10-11(21-10)15(7,13)18/h6-11,16,18H,1,4H2,2-3H3/t6-,7+,8+,9+,10+,11-,13-,14+,15-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Tutin

The herbs of Coriaria nepalensis Wall.

Biological Activity of Tutin

Description1. Tutin in honey, is a plant-derived neurotoxin.

Tutin Dilution Calculator

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Tutin Molarity Calculator

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Preparing Stock Solutions of Tutin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3979 mL 16.9895 mL 33.9789 mL 67.9579 mL 84.9473 mL
5 mM 0.6796 mL 3.3979 mL 6.7958 mL 13.5916 mL 16.9895 mL
10 mM 0.3398 mL 1.6989 mL 3.3979 mL 6.7958 mL 8.4947 mL
50 mM 0.068 mL 0.3398 mL 0.6796 mL 1.3592 mL 1.6989 mL
100 mM 0.034 mL 0.1699 mL 0.3398 mL 0.6796 mL 0.8495 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Tutin

Sweet Poisons: Honeys Contaminated with Glycosides of the Neurotoxin Tutin.[Pubmed:25993882]

J Nat Prod. 2015 Jun 26;78(6):1363-9.

Poisonings due to consumption of honeys containing plant toxins have been reported widely. One cause is the neurotoxin Tutin, an oxygenated sesquiterpene picrotoxane, traced back to honeybees (Apis mellifera) collecting honeydew produced by passionvine hoppers (Scolypopa australis) feeding on sap of the poisonous shrub tutu (Coriaria spp.). However, a pharmacokinetic study suggested that unidentified conjugates of Tutin were also present in such honeys. We now report the discovery, using ion trap LC-MS, of two Tutin glycosides and their purification and structure determination as 2-(beta-d-glucopyranosyl)Tutin (4) and 2-[6'-(alpha-d-glucopyranosyl)-beta-d-glucopyranosyl]Tutin (5). These compounds were used to develop a quantitative triple quadrupole LC-MS method for honey analysis, which showed the presence of Tutin (3.6 +/- 0.1 mug/g honey), hyenanchin (19.3 +/- 0.5), Tutin glycoside (4) (4.9 +/- 0.4), and Tutin diglycoside (5) (4.9 +/- 0.1) in one toxic honey. The ratios of 4 and 5 to Tutin varied widely in other Tutin-containing honeys. The glycosidation of Tutin may represent detoxification by one or both of the insects involved in the food chain from plant to honey.

Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin.[Pubmed:25084484]

Food Chem Toxicol. 2014 Oct;72:234-41.

Over the last 150 years a number of people in New Zealand have been incapacitated, hospitalised, or died from eating honey contaminated with Tutin, a plant-derived neurotoxin. A feature of the most recent poisoning incident in 2008 was the large variability in the onset time of clinical signs and symptoms of toxicity (0.5-17 h). To investigate the basis of this variability a pharmacokinetic study was undertaken in which 6 healthy males received a single oral dose of Tutin-containing honey giving a Tutin dose of 1.8 mug/kg body weight. The serum concentration-time curve for all volunteers exhibited two discrete peaks with the second and higher level occurring at approximately 15 h post-dose. Two subjects reported mild, transient headache at a time post-dose corresponding to maximum Tutin concentrations. There were no other signs or symptoms typical of Tutin intoxication such as nausea, vomiting, dizziness or seizures. Pharmacokinetic analysis using a two-site absorption model resulted in a good fit to the observed concentration data. A novel analytical method subsequently revealed the presence of glycoside conjugates of Tutin in addition to unconjugated Tutin in honey. These pharmacokinetic data will be important to better define a safe maximum Tutin concentration in honey.

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