TetrahydroalstonineCAS# 6474-90-4 |
- Mayumbine
Catalog No.:BCN5123
CAS No.:25532-45-0
- Ajmalicine
Catalog No.:BCN5577
CAS No.:483-04-5
- Akuammigine
Catalog No.:BCN4607
CAS No.:642-17-1
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 6474-90-4 | SDF | Download SDF |
| PubChem ID | 72340 | Appearance | Solid |
| Formula | C21H24N2O3 | M.Wt | 352.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 | ||
| Standard InChIKey | GRTOGORTSDXSFK-DLLGKBFGSA-N | ||
| Standard InChI | InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16-,19-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Tetrahydroalstonine and Raubasine preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to exogenous and endogenouse noradrenaline, respectively. |
| Targets | Adrenergic Receptor |
| In vivo | Differential inhibition of raubasine and tetrahydroalstonine on the vasopressor response to sympathetic nervous stimulation and intravenous noradrenaline in the pithed rat[Pubmed: 2869187]J Pharmacol. 1985 Oct-Dec;16(4):412-20.The effects of raubasine and Tetrahydroalstonine (THA) on the vasopressor response to sympathetic nerve stimulation and to i.v. administration of noradrenaline were studied in the pithed rat to ascertain whether raubasine and THA would preferentially block pressor responses due to exogenous versus endogenous noradrenaline alpha-adrenergic receptor activation. |
| Kinase Assay | Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine.[Pubmed: 6099269]Eur J Pharmacol. 1984 Oct 30;106(1):203-5.
|
Tetrahydroalstonine Dilution Calculator
Tetrahydroalstonine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8377 mL | 14.1884 mL | 28.3768 mL | 56.7537 mL | 70.9421 mL |
| 5 mM | 0.5675 mL | 2.8377 mL | 5.6754 mL | 11.3507 mL | 14.1884 mL |
| 10 mM | 0.2838 mL | 1.4188 mL | 2.8377 mL | 5.6754 mL | 7.0942 mL |
| 50 mM | 0.0568 mL | 0.2838 mL | 0.5675 mL | 1.1351 mL | 1.4188 mL |
| 100 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.5675 mL | 0.7094 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- RA-V
Catalog No.:BCN3513
CAS No.:64725-24-2
- Morin dihydrate
Catalog No.:BCN8156
CAS No.:6472-38-4
- Cinaciguat hydrochloride
Catalog No.:BCC8096
CAS No.:646995-35-9
- Dihydroflavokawain C
Catalog No.:BCC9229
CAS No.:
- Demethylwedelolactone
Catalog No.:BCN2663
CAS No.:6468-55-9
- Coleonol B
Catalog No.:BCN4188
CAS No.:64657-21-2
- 1,9-Dideoxyforskolin
Catalog No.:BCC6352
CAS No.:64657-18-7
- Demethylluvangetin
Catalog No.:BCN7569
CAS No.:64652-10-4
- VcMMAE
Catalog No.:BCC2033
CAS No.:646502-53-6
- H-D-Glu(OMe)-OH
Catalog No.:BCC2940
CAS No.:6461-04-7
- Sinigrin monohydrate
Catalog No.:BCN2595
CAS No.:64550-88-5
- Acantrifoside E
Catalog No.:BCN6646
CAS No.:645414-25-1
- 1,2,3,6,7-Pentamethoxyxanthone
Catalog No.:BCN7525
CAS No.:64756-86-1
- 6-Hydroxy-1,2,3,7-tetramethoxyxanthone
Catalog No.:BCN7565
CAS No.:64756-87-2
- L-trans-2,4-PDC
Catalog No.:BCC6595
CAS No.:64769-66-0
- Betulalbuside A
Catalog No.:BCN4190
CAS No.:64776-96-1
- Trilobatin 2''-acetate
Catalog No.:BCN4191
CAS No.:647853-82-5
- Glucagon (19-29), human
Catalog No.:BCC1012
CAS No.:64790-15-4
- Heraclenol acetonide
Catalog No.:BCN4192
CAS No.:64790-68-7
- Neomangiferin
Catalog No.:BCN4970
CAS No.:64809-67-2
- Vitexin-2''-O-rhamnoside
Catalog No.:BCN5025
CAS No.:64820-99-1
- ophocarpine hydrobromide
Catalog No.:BCN7541
CAS No.:78003-71-1
- AS-604850
Catalog No.:BCC4989
CAS No.:648449-76-7
- AS-605240
Catalog No.:BCC2495
CAS No.:648450-29-7
[Differential inhibition of raubasine and tetrahydroalstonine on the vasopressor response to sympathetic nervous stimulation and intravenous noradrenaline in the pithed rat].[Pubmed:2869187]
J Pharmacol. 1985 Oct-Dec;16(4):412-20.
The effects of raubasine and Tetrahydroalstonine (THA) on the vasopressor response to sympathetic nerve stimulation and to i.v. administration of noradrenaline were studied in the pithed rat to ascertain whether raubasine and THA would preferentially block pressor responses due to exogenous versus endogenous noradrenaline alpha-adrenergic receptor activation. Raubasine (0.5 to 4 mg/kg i.v.) was more effective in blocking the response due to sympathetic nerve stimulation than that due to i.v. noradrenaline. On the other hand THA (0.5 to 4 mg/kg i.v.) produced greater inhibition of the i.v. noradrenaline response than the sympathetic nerve stimulation response. THA (0.5, 1, 2 mg/kg i.v.) enhanced the nerve stimulation response, while at the 4 mg/kg dose the response was slightly reduced. This may be explained by a preferential block by THA at low doses, of presynaptic alpha 2-adrenoceptors. In pithed rat raubasine and THA showed dose-related blocking effects on the pressor response of phenylephrine and B-HT 933, respectively. This suggest that raubasine preferentially blocks alpha-1 and THA alpha 2-adrenoceptors. The results suggest that raubasine and THA preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to endogenous and exogenous noradrenaline, respectively.
Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine.[Pubmed:6099269]
Eur J Pharmacol. 1984 Oct 30;106(1):203-5.
The relative potencies of raubasine, Tetrahydroalstonine (THA) and akuammigine on alpha 1- and alpha 2-adrenoceptors were assessed by comparing their effects on the rise in blood pressure induced by stimulation of the sympathetic outflow from the spinal cord or by injection of noradrenaline in pithed rats. Akuammigine was inactive in both cases. Raubasine preferentially antagonized the effects of electrical stimulation while THA antagonized the effects of injected noradrenaline. The results suggest that raubasine preferentially blocks alpha 1-adrenoceptors while THA is more selective for alpha 2-adrenoceptors.
