RosenonolactoneCAS# 508-71-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 508-71-4 | SDF | Download SDF |
| PubChem ID | 11723309 | Appearance | Powder |
| Formula | C20H28O3 | M.Wt | 316.4 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1(CCC2(C(C1)C(=O)CC3C24CCCC3(C(=O)O4)C)C)C=C | ||
| Standard InChIKey | HWECMADGHQKSLK-BWXAORSUSA-N | ||
| Standard InChI | InChI=1S/C20H28O3/c1-5-17(2)9-10-19(4)13(12-17)14(21)11-15-18(3)7-6-8-20(15,19)23-16(18)22/h5,13,15H,1,6-12H2,2-4H3/t13-,15-,17+,18-,19+,20+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin. |
Rosenonolactone Dilution Calculator
Rosenonolactone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1606 mL | 15.8028 mL | 31.6056 mL | 63.2111 mL | 79.0139 mL |
| 5 mM | 0.6321 mL | 3.1606 mL | 6.3211 mL | 12.6422 mL | 15.8028 mL |
| 10 mM | 0.3161 mL | 1.5803 mL | 3.1606 mL | 6.3211 mL | 7.9014 mL |
| 50 mM | 0.0632 mL | 0.3161 mL | 0.6321 mL | 1.2642 mL | 1.5803 mL |
| 100 mM | 0.0316 mL | 0.158 mL | 0.3161 mL | 0.6321 mL | 0.7901 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Enzyme inhibitory constituents from Duranta repens.[Pubmed:11964000]
Chem Pharm Bull (Tokyo). 2002 Apr;50(4):515-8.
Isoprenylated flavonoids 5,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-3,6,4'-trimethoxyflavone (1), 3,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-5,6,4'-trimethoxyflavone (2) and an isoprenylated acetophenone derivative (3) have been isolated from Duranta repens along with known compounds, 5-hydroxy-3,6,7,4'-tetramethoxyflavone (4), Rosenonolactone (5), 6,7-dimethoxycoumarin (6), 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (7) and 5alpha,8alpha-epidioxyergosta-6,9(11),22-trien-3beta-ol (8), isolated for the first time from this species. Their structures and the relative configuration were determined by spectroscopic methods (1H- and 13C-NMR, IR, UV and MS) and two-dimensional (2D)-NMR experiments. The compounds 1-5 showed inhibitory activity against prolyl endopeptidase while 4 and 5 were also active against thrombin.
DNA strand break induction, mutagenicity, and cytotoxicity of the mycotoxins 11-beta-hydroxy-7-deoxy-rosenonolactone, rosenonolactone, and trichothecin.[Pubmed:23606003]
Mycotoxin Res. 1992 Sep;8(2):77-83.
11-beta-hydroxy-7-deoxy-Rosenonolactone (TSS1), a mycotoxin of the rosenane class, was tested on cytotoxicity, induction of DNA single strand breaks and muta-genicity. Its effects were compared to those of Rosenonolactone and trichothecin. TSS1 had stronger antibiotic activity againstEscherichia coli (EC 50: 10mug/mL) than Rosenonolactone (EC 50: >200mug/mL) but weaker activity than trichothecin (EC 50: 3mug/mL). The same order of activity was found for the inhibition of yeast fermentation (EC 50 of TSS1: 45mug/mL; EC 50 of Rosenonolactone: > 120mug/mL; EC 50 of trichothecin: 3.4mug/mL).In the trypan blue exclusion test using V79 Chinese hamster cells, TSS1 proved to be cytotoxic (EC50: 30mug/mL) at even lower doses than trichothecin (EC50: 200mug/mL). Rosenonolactone had no significant toxicity up to the highest soluble concentration (500mug/mL).DNA single strand breaks caused by TSS1 occurred at the same concentrations at which damage of the cell membrane became apparent. For trichothecin single strand breaks were detected only at concentrations at which the membrane was already highly damaged. No single strand breaks were observed in V79 cells after incubation with Rosenonolactone up to the limit of solubility (500mug/mL).In the reversion assay withhis Salmonella typhimurium strains TA 98 and TA 100, no mutagenicity was observed for any of the examined mycotoxins up to 800mug/plate with and without the addition of a rat liver preparation for metabolism of the test compound.
