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Pseudolaric acid B-O-beta-D-glucopyranoside

CAS# 98891-41-9

Pseudolaric acid B-O-beta-D-glucopyranoside

Catalog No. BCN1291----Order now to get a substantial discount!

Product Name & Size Price Stock
Pseudolaric acid B-O-beta-D-glucopyranoside:5mg Please Inquire In Stock
Pseudolaric acid B-O-beta-D-glucopyranoside:10mg Please Inquire In Stock
Pseudolaric acid B-O-beta-D-glucopyranoside:20mg Please Inquire In Stock
Pseudolaric acid B-O-beta-D-glucopyranoside:50mg Please Inquire In Stock

Quality Control of Pseudolaric acid B-O-beta-D-glucopyranoside

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Chemical structure

Pseudolaric acid B-O-beta-D-glucopyranoside

3D structure

Chemical Properties of Pseudolaric acid B-O-beta-D-glucopyranoside

Cas No. 98891-41-9 SDF Download SDF
PubChem ID 10031398 Appearance White powder
Formula C29H38O13 M.Wt 594.6
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in chloroform, DMSO and ethan
SMILES CC(=CC=CC1(C2CCC3(C2(CCC(=CC3)C(=O)OC)OC(=O)C)C(=O)O1)C)C(=O)OC4C(C(C(C(O4)CO)O)O)O
Standard InChIKey UUDZDKPKXAEKLA-YHLOYHKPSA-N
Standard InChI InChI=1S/C29H38O13/c1-15(23(35)40-25-22(34)21(33)20(32)18(14-30)39-25)6-5-10-27(3)19-9-12-28(26(37)42-27)11-7-17(24(36)38-4)8-13-29(19,28)41-16(2)31/h5-7,10,18-22,25,30,32-34H,8-9,11-14H2,1-4H3/b10-5+,15-6+/t18-,19+,20-,21+,22-,25+,27-,28-,29+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pseudolaric acid B-O-beta-D-glucopyranoside

The root bark of Pseudolarix amabilis

Biological Activity of Pseudolaric acid B-O-beta-D-glucopyranoside

DescriptionPseudolaric acid B-O-beta-D-glucopyranoside is a natural product from Pseudolarix amabilis.
In vivo

Metabolic pathway and metabolites of total diterpene acid isolated from Pseudolarix kaempferi.[Pubmed: 25322560]

Yao Xue Xue Bao. 2014 Aug;49(8):1169-74.

The preliminary metabolic profile of total diterpene acid (TDA) isolated from Pseudolarix kaempferi was investigated by using in vivo and in vitro tests.
METHODS AND RESULTS:
Pseudolaric acid C2 (PC2) was identified as the predominant metabolite in plasma, urine, bile and feces after both oral and intravenous administrations to rats using HPLC-UV and HPLC-ESI/MS(n), and demethoxydeacetoxypseudolaric acid B (DDPB), a metabolite proposed to be the glucoside of PC2 (PC2G), as well as pseudolaric acid C (PC), pseudolaric acid A (PA), Pseudolaric acid A-O-beta-D-glucopyranoside (PAG), Pseudolaric acid B-O-beta-D-glucopyranoside (PBG) and deacetylpseudolaric acid A (DPA) originated from TDA could also be detected. It was demonstrated by tests that the metabolism of TDA is independent of intestinal microflora, and neither of pepsin and trypsin is in charge of metabolism of TDA, TDA is also stable in both pH environments of gastric tract and intestinal tract. The metabolites of TDA in whole blood in vitro incubation were found to be PC2, DDPB and PC2G, which demonstrated that the metabolic reaction of TDA in vivo is mainly occurred in blood and contributed to be the hydrolysis of plasma esterase to ester bond, as well as the glucosylation reaction.
CONCLUSIONS:
These results clarified the metabolic pathway of TDA for the first time, which is of great significance to the in vivo active form and acting mechanism research of P. kaempferi.

Protocol of Pseudolaric acid B-O-beta-D-glucopyranoside

Structure Identification
J. Nat. Prod., 2002, 65 (7), pp 1041–1044

Five New Diterpenoids from Pseudolarix kaempferi[Reference: WebLink]


METHODS AND RESULTS:
Five new diterpenoids, pseudolaric acids F (1), G (2), and H (3), 2‘,3‘-dihydroxy-1‘-propoxypseudolarate B (4), and 6‘-O-acetylpseudolaric acid B O-β-d-glucopyranoside (5), along with nine known diterpenoids, pseudolaric acids A, B, and C1, deacetylpseudolaric acid C2, deacetylpseudolaric acid A, methyl pseudolarate A, methyl pseudolarate B, pseudolaric acid A-O-β-d-glucopyranoside, and Pseudolaric acid B-O-beta-D-glucopyranoside, were isolated from the root bark of Pseudolarix kaempferi.
CONCLUSIONS:
Their structures and stereochemistry were elucidated mainly by spectral data, especially 2D NMR techniques.

Pseudolaric acid B-O-beta-D-glucopyranoside Dilution Calculator

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Pseudolaric acid B-O-beta-D-glucopyranoside Molarity Calculator

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Preparing Stock Solutions of Pseudolaric acid B-O-beta-D-glucopyranoside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6818 mL 8.409 mL 16.818 mL 33.6361 mL 42.0451 mL
5 mM 0.3364 mL 1.6818 mL 3.3636 mL 6.7272 mL 8.409 mL
10 mM 0.1682 mL 0.8409 mL 1.6818 mL 3.3636 mL 4.2045 mL
50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6727 mL 0.8409 mL
100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pseudolaric acid B-O-beta-D-glucopyranoside

[Metabolic pathway and metabolites of total diterpene acid isolated from Pseudolarix kaempferi].[Pubmed:25322560]

Yao Xue Xue Bao. 2014 Aug;49(8):1169-74.

The preliminary metabolic profile of total diterpene acid (TDA) isolated from Pseudolarix kaempferi was investigated by using in vivo and in vitro tests. Pseudolaric acid C2 (PC2) was identified as the predominant metabolite in plasma, urine, bile and feces after both oral and intravenous administrations to rats using HPLC-UV and HPLC-ESI/MS(n), and demethoxydeacetoxypseudolaric acid B (DDPB), a metabolite proposed to be the glucoside of PC2 (PC2G), as well as pseudolaric acid C (PC), pseudolaric acid A (PA), pseudolaric acid A O-beta-D glucopyranoside (PAG), pseudolaric acid B O-beta-D glucopyranoside (PBG) and deacetylpseudolaric acid A (DPA) originated from TDA could also be detected. It was demonstrated by tests that the metabolism of TDA is independent of intestinal microflora, and neither of pepsin and trypsin is in charge of metabolism of TDA, TDA is also stable in both pH environments of gastric tract and intestinal tract. The metabolites of TDA in whole blood in vitro incubation were found to be PC2, DDPB and PC2G, which demonstrated that the metabolic reaction of TDA in vivo is mainly occurred in blood and contributed to be the hydrolysis of plasma esterase to ester bond, as well as the glucosylation reaction. These results clarified the metabolic pathway of TDA for the first time, which is of great significance to the in vivo active form and acting mechanism research of P. kaempferi.

Description

Pseudolaric acid B β-D-glucoside is a diterpenoid isolated from Pseudolarix kaempferi.

Keywords:

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